Gene interactions and pathways from curated databases and text-mining
Mol Cell Neurosci 1998, PMID: 9647693

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

Wood, J D; Yuan, J; Margolis, R L; Colomer, V; Duan, K; Kushi, J; Kaminsky, Z; Kleiderlein, J J; Sharp, A H; Ross, C A

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy (DRPLA). The normal function of atrophin-1 is unknown. We have identified five atrophin-1 interacting proteins (AIPs) which bind to atrophin-1 in the vicinity of the polyglutamine tract using the yeast two-hybrid system. Four of the interactions were confirmed using in vitro binding assays. All five interactors contained multiple WW domains. Two are novel. The AIPs can be divided into two distinct classes. AIP1 and AIP3/WWP3 are MAGUK-like multidomain proteins containing a number of protein-protein interaction modules, namely a guanylate kinase-like region, two WW domains, and multiple PDZ domains. AIP2/WWP2, AIP4, and AIP5/WWP1 are highly homologous, each having four WW domains and a HECT domain characteristic of ubiquitin ligases. These interactors are similar to recently isolated huntingtin-interacting proteins, suggesting possible commonality of function between two proteins responsible for very similar diseases.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Bind Interaction: ATN1 — ITCH
  • IRef Bind Interaction: ATN1 — WWP1
  • IRef Bind Interaction: ATN1 — MAGI2
  • IRef Bind Interaction: ATN1 — WWP2
  • IRef Bind_translation Interaction: ATN1 — MAGI1 (two hybrid)
  • IRef Bind_translation Interaction: ATN1 — MAGI1 (affinity chromatography technology)
  • IRef Bind_translation Interaction: ATN1 — ITCH (affinity chromatography technology)
  • IRef Bind_translation Interaction: ATN1 — ITCH (two hybrid)
  • IRef Bind_translation Interaction: ATN1 — WWP1 (two hybrid)
  • IRef Bind_translation Interaction: ATN1 — MAGI2 (two hybrid)
  • IRef Bind_translation Interaction: ATN1 — MAGI2 (affinity chromatography technology)
  • IRef Bind_translation Interaction: ATN1 — WWP2 (two hybrid)
  • IRef Bind_translation Interaction: ATN1 — WWP2 (affinity chromatography technology)
  • IRef Biogrid Interaction: ITCH — ATN1 (direct interaction, pull down)
  • IRef Biogrid Interaction: ITCH — ATN1 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: ATN1 — WWP2 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: ATN1 — WWP2 (direct interaction, pull down)
  • IRef Biogrid Interaction: ATN1 — MAGI1 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: ATN1 — MAGI1 (direct interaction, pull down)
  • IRef Biogrid Interaction: ATN1 — WWP1 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: MAGI2 — ATN1 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: MAGI2 — ATN1 (direct interaction, pull down)
  • Gene Ontology Complexes ubiquitin ligase complex: ubiquitin ligase complex complex (WWP2-RNF11-UBE2D2-TSPAN17-HSPA1A-DYRK2-CBLL1-CBX8-GPR37-TOPORS-SUGT1-FBXL7-MIB2-FBXL12-FBXO25-FBXW4-ARIH1-TRAF7-BRCC3-UBE2E1-BRAP-UBR2-RNF20-UBE4A-DNAJA1-FBXL4-RING1-RNF144B-RNF8-RNF2-UBE2L3)
  • IRef Hprd Interaction: ITCH — ATN1 (in vitro)
  • IRef Hprd Interaction: ITCH — ATN1 (two hybrid)
  • IRef Hprd Interaction: WWP2 — ATN1 (in vitro)
  • IRef Hprd Interaction: WWP2 — ATN1 (in vivo)
  • IRef Hprd Interaction: WWP2 — ATN1 (two hybrid)
  • IRef Hprd Interaction: ATN1 — ATN1 (two hybrid)
  • IRef Hprd Interaction: ATN1 — ATN1 (in vitro)
  • IRef Hprd Interaction: MAGI1 — ATN1 (in vitro)
  • IRef Hprd Interaction: MAGI1 — ATN1 (two hybrid)
  • IRef Hprd Interaction: ATN1 — WWP1 (two hybrid)
  • IRef Hprd Interaction: PDCD6IP — ATN1 (in vitro)
  • IRef Hprd Interaction: PDCD6IP — ATN1 (two hybrid)
  • IRef Hprd Interaction: MAGI2 — ATN1 (in vitro)
  • IRef Hprd Interaction: MAGI2 — ATN1 (two hybrid)
  • IRef Ophid Interaction: ATN1 — MAGI1 (aggregation, confirmational text mining)
  • IRef Ophid Interaction: ATN1 — WWP1 (aggregation, confirmational text mining)
In total, 472 gene pairs are associated to this article in curated databases