Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866144-178957881)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
Gene:               Hide non-PIK3CA interactions     Show top Genes on graph    

Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

EGF ▸ RAC1 ▸ EGFR ▸ IL6 ▸ NOS3 ▸ TNF ▸ MMP9 ▸
IRS1 ▸ LEP ▸ PTGS2 ▸ PI3 ▸ IL8 ▸ HMOX1 ▸ ANXA6 ▸
FOXO3 ▸ IRF6 ▸ CASP3 ▸ CASP9 ▸ CASP1 ▸ CASP4 ▸ CASP14 ▸
CASP12 ▸ CASP2 ▸ CASP7 ▸ CASP5 ▸ CASP16 ▸ SRC ▸ CASP8 ▸
CASP6 ▸ BCR ▸ BCL2 ▸ CASP10 ▸ HIF1A ▸ GSK3B ▸ JUN ▸
IL12B ▸ IL12A ▸ HGF ▸ IL2 ▸ FOXO1 ▸ NOS2 ▸ IL10 ▸
CCND1 ▸ STAT3 ▸ TLR4 ▸ CD28 ▸ FGF2 ▸ NGF ▸ MLST8 ▸
RAC2 ▸ KRAS ▸ CTNNB1 ▸ ESR1 ▸ NOX3 ▸ NOX5 ▸ TLR2 ▸
BDNF ▸ CBFA2T2 ▸ RAC3 ▸ NOX1 ▸ MMP2 ▸ NOX4 ▸ PTPN11 ▸
TP53 ▸ IRS2 ▸ RAF1 ▸ IL1B ▸ CRK ▸ RHOA ▸ RPTOR ▸
CDC42 ▸ CREB3 ▸ MAP2K1 ▸ JAK2 ▸ ARHGEF7 ▸ HRAS ▸ CREB5 ▸
CD79A ▸ CREB1 ▸ PRKAG1 ▸ PRKAB2 ▸ CD79B ▸ PRKAA1 ▸ PRKAB1 ▸
CDKN1A ▸ PRKAG2 ▸ PRKAA2 ▸ GRAP2 ▸ IGF2 ▸ PRKAR2B ▸ PRKACB ▸
PRKAR1B ▸ IFI27 ▸ PRKAR1A ▸ MCL1 ▸ CBL ▸ HSPG2 ▸ GAB1 ▸
BMP2 ▸ PRKAR2A ▸ MMP14 ▸ PRKACG ▸ SMAD2 ▸ IFNG ▸ SETD2 ▸
STAT1 ▸ BCL10 ▸ FOS ▸ FAS ▸ PDGFB ▸ SLC2A4 ▸ RAD50 ▸
SLC25A16 ▸ TLR5 ▸ PARP1 ▸ PLCG1 ▸ TCF12 ▸ ANGPT2 ▸ TCF21 ▸
MMP12 ▸ POT1 ▸ PIK3R1 ▸ PRKCA ▸ IL4 ▸ ACD ▸ BAX ▸
TERF2IP ▸ TERF1 ▸ IGF1R ▸ CXCL12 ▸ MMP13 ▸ TCF19 ▸ MMP7 ▸
XRCC6 ▸ JAK1 ▸ TCF15 ▸ IL3 ▸ PIK3CB ▸ TCF24 ▸ TCF7 ▸
PTK2 ▸ IL17A ▸ TLR3 ▸ TCF20 ▸ AHSA1 ▸ ESR2 ▸ TCF25 ▸
PDGFRB ▸ TCF3 ▸ TERF2 ▸ RPS6KB1 ▸ PHKA2 ▸ TCF4 ▸ MRE11A ▸
TGFB1 ▸ TCF23 ▸ TINF2 ▸ PIK3CD ▸ MMP10 ▸ XRCC5 ▸ XIAP ▸
TMED7 ▸ SYK ▸ MMP17 ▸ TLR1 ▸ MMP3 ▸ ICAM1 ▸ RAB5A ▸
NOS1 ▸ MMP19 ▸ EIF4EBP1 ▸ SP1 ▸ MMP27 ▸ ILK ▸ TLR8 ▸
MMP1 ▸ MMP26 ▸ CTGF ▸ FOXO6 ▸ MMP20 ▸ TLR10 ▸ VCAM1 ▸
MMP8 ▸ MMP15 ▸ PLD2 ▸ TLR7 ▸ MMP21 ▸ GJA1 ▸ TLR6 ▸
JAK3 ▸ MYLIP ▸ MYD88 ▸ SREBF1 ▸ MMP16 ▸ PLAU ▸ FOXO4 ▸
MMP25 ▸ PRL ▸ MMP11 ▸ IKBKG ▸ TLR9 ▸ MMP28 ▸ SLC2A1 ▸
MMP24 ▸ ZGLP1 ▸ STK31 ▸ ECM2 ▸ STK19 ▸ STK33 ▸ IL18 ▸
RICTOR ▸ CA2 ▸ SLC22A3 ▸ CDH1 ▸ PIP ▸ FYN ▸ KITLG ▸
HSP90AA1 ▸ STK39 ▸ ECM1 ▸ INSR ▸ STK35 ▸ GDNF ▸ NTRK1 ▸
PTK6 ▸ STK38 ▸ NFKBIA ▸ BCL9 ▸ EPO ▸ WNK1 ▸ LPA ▸
PLCG2 ▸ GYS2 ▸ SMAD1 ▸ IL13 ▸ STK36 ▸ PLA2G1B ▸ FOSL1 ▸
SMAD4 ▸ SMAD5 ▸ STK10 ▸ BTK ▸ MET ▸ CXCL11 ▸ BCL5 ▸
SERPINE1 ▸ BCL3 ▸ STK25 ▸ TGFB2 ▸ GRB2 ▸ STK24 ▸ STK40 ▸
LCK ▸ STK3 ▸ CSF1 ▸ PDLIM7 ▸ FGF21 ▸ STK11 ▸ IL7 ▸
PTK7 ▸ SYT1 ▸ GYS1 ▸ STK16 ▸ HRG ▸ BCL6 ▸ STK4 ▸
FGF7 ▸ FGF3 ▸ CD4 ▸ PDK1 ▸ RUNX2 ▸ RLN2 ▸ GAB2 ▸
BRAF ▸ CDC73 ▸ BPNT1 ▸ RLN3 ▸ PIK3CG ▸ CCND2 ▸ NPY4R ▸
NA ▸ WNT4 ▸ HDAC2 ▸ FGF17 ▸ FGF9 ▸ CXCL9 ▸ CAV3 ▸
CCNG1 ▸ FGF19 ▸ IL5 ▸ SMAD9 ▸ FASLG ▸ FGF4 ▸ FGF11 ▸
HDAC1 ▸ AR ▸ TAT ▸ CXCR4 ▸ HDAC3 ▸ MYC ▸ FGF12 ▸
PIK3IP1 ▸ CAV1 ▸ FGF22 ▸ TNFSF13B ▸ VAV1 ▸ CYP19A1 ▸ STAT6 ▸
EGR1 ▸ CALM3 ▸ SOAT1 ▸ FGF20 ▸ IL1A ▸ GPR15 ▸ SHC1 ▸
PAK2 ▸ SMAD6 ▸ IL32 ▸ PPP1R3A ▸ PLD1 ▸ ADORA3 ▸ AKT1S1 ▸
PBK ▸ PLD3 ▸ PPARG ▸ FGF16 ▸ BMP6 ▸ CAT ▸ LGALS3 ▸
FGF6 ▸ NANOG ▸ NTRK2 ▸ CAV2 ▸ FGF18 ▸ F2RL1 ▸ FGF14 ▸
BAD ▸ RBBP4 ▸ FGF5 ▸ CTLA4 ▸ SMAD3 ▸ ERBB2 ▸ FGF8 ▸
FGF23 ▸ EHMT1 ▸ SGK1 ▸ PLD6 ▸ ADORA1 ▸ RNF19A ▸ PAK1 ▸
IL11 ▸ RLN1 ▸ FGF10 ▸ PLD4 ▸ IL24 ▸ SGK3 ▸ PLD5 ▸
TNFSF10 ▸ PCNA ▸ ATP5O ▸ SPP1 ▸ FGF1 ▸ TPO ▸ PLA2G4A ▸
RBBP7 ▸ ODC1 ▸ SMAD7 ▸ ITGB1 ▸ ABCB1 ▸ HSPB1 ▸ KIT ▸
GSK3A ▸ PDE3B ▸ FGF13 ▸ GPER1 ▸ CEBPA ▸ GPR52 ▸ PTH ▸
CDC16 ▸ GPR155 ▸ GPR123 ▸ GPR107 ▸ NFE2L2 ▸ GPR153 ▸ GPR132 ▸
GPR160 ▸ IL27 ▸ MYOG ▸ MDM2 ▸ IL6ST ▸ GPR17 ▸ GPR25 ▸
GPR19 ▸ AQP3 ▸ GPR98 ▸ GPR179 ▸ GPR110 ▸ WNT16 ▸ CHKA ▸
CDH5 ▸ IL25 ▸ GPR116 ▸ GPR183 ▸ GPR97 ▸ IL16 ▸ WNT1 ▸
GPR3 ▸ GPR139 ▸ CSF2 ▸ PKD3 ▸ CDC37 ▸ CDC7 ▸ TFRC ▸
GPR87 ▸ BMP5 ▸ MAP3K5 ▸ MT3 ▸ MUC1 ▸ BSG ▸ PAK3 ▸
NRG1 ▸ GTPBP1 ▸ PDX1 ▸ BMP7 ▸ GPR78 ▸ GPR45 ▸ GPR42 ▸
GPR171 ▸ ITGA5 ▸ IL33 ▸ PREX1 ▸ SST ▸ NTRK3 ▸ CCL2 ▸
IL26 ▸ CD19 ▸ DAB2IP ▸ GPR39 ▸ PKD1 ▸ CCK ▸ ITGB4 ▸
ERBB4 ▸ GPR149 ▸ GPR88 ▸ SKP2 ▸ UCN ▸ ADRBK1 ▸ NM ▸
LDLR ▸ GPR180 ▸ CDC45 ▸ WNT3 ▸ BMP10 ▸ TYR ▸ GPR157 ▸
HMGB1 ▸ CDC27 ▸ FGFR2 ▸ CD38 ▸ GPR50 ▸ IL9 ▸ CDC26 ▸
LYN ▸ GPR82 ▸ PAK6 ▸ GPS2 ▸ GPR31 ▸ GPR36 ▸ CD2 ▸
IGFBP3 ▸ PKD2 ▸ GPR34 ▸ CXCL10 ▸ CX3CL1 ▸ NCF1 ▸ PRKCZ ▸
GPR112 ▸ GPR33 ▸ IL19 ▸ PLAT ▸ WNT6 ▸ GPR75 ▸ PAK4 ▸
CD86 ▸ GPR152 ▸ GPR63 ▸ ITIH4 ▸ ARSK ▸ BIRC2 ▸ CCDC88A ▸
MAP3K7 ▸ RBL2 ▸ WNT2 ▸ UVRAG ▸ GPR61 ▸ GPR141 ▸ SNAI2 ▸
GPR35 ▸ NOTCH1 ▸ GPR150 ▸ GPR65 ▸ NTF3 ▸ PGP ▸ WNT11 ▸
BRCA1 ▸ GPR22 ▸ GPR176 ▸ PSEN1 ▸ GPR27 ▸ CDC20 ▸ CDK5 ▸
GNE ▸ ICOS ▸ NFAT5 ▸ TSC2 ▸ MOK ▸ GPR115 ▸ GPR32 ▸
SLPI ▸ BMP4 ▸ PRDX2 ▸ CDC34 ▸ CD14 ▸ GPR68 ▸ TGFB3 ▸
IFNB1 ▸ GPR113 ▸ DAB1 ▸ NCF4 ▸ PTTG1 ▸ ARAF ▸ GPR101 ▸
LIF ▸ IL20 ▸ GRP ▸ CDC123 ▸ GPR128 ▸ IL1RN ▸ GPR6 ▸
ADAM12 ▸ VEGFC ▸ GPR173 ▸ CDC6 ▸ SLC9A1 ▸ ABL1 ▸ GPR142 ▸
GPR124 ▸ GPR111 ▸ GPR125 ▸ GPR83 ▸ DDIT3 ▸ BMP15 ▸ GPR133 ▸
CPOX ▸ GPR135 ▸ GPR62 ▸ GPR146 ▸ GPR18 ▸ SIRT1 ▸ GDF15 ▸
GPR114 ▸ GPR162 ▸ GPR126 ▸ IKBKB ▸ C1orf228 ▸ CORO2A ▸ ITGA6 ▸
IL31 ▸ IL37 ▸ BMP1 ▸ CDC23 ▸ SMN1 ▸ IL21 ▸ RPL17 ▸
GPR144 ▸ PTGES ▸ BMP3 ▸ CHUK ▸ AGTR2 ▸ FOXP3 ▸ GPR156 ▸
GPR55 ▸ GPR21 ▸ RHEB ▸ CEBPB ▸ IL15 ▸ PLEK ▸ NCOR1 ▸
CALM2 ▸ GPR151 ▸ GPR161 ▸ GPR158 ▸ GPR108 ▸ IL22 ▸ GPR1 ▸
IRS4 ▸ GPR137 ▸ LTB ▸ GPR143 ▸ GPR182 ▸ E2F1 ▸ TBL1XR1 ▸
GPR12 ▸ HBEGF ▸ ANG ▸ GPR26 ▸ GPR56 ▸ TRNAE1 ▸ GPR119 ▸
CALM1 ▸ GPR20 ▸ RAE1 ▸ GAPDH ▸ PAK7 ▸ IRF1 ▸ MUC8 ▸
GPR4 ▸ GPR84 ▸ FGR ▸ GPR174 ▸ GPR37 ▸ MSC ▸ GPR148 ▸
MYCN ▸ SOCS3 ▸ GPR85 ▸ CSE ▸ GPR64 ▸ CDC40 ▸ GPR79 ▸
TBL1X ▸ IL34 ▸ HIST2H2AC ▸ PIP5K1B ▸ CBLB ▸ DDX17 ▸ CNTRL ▸
HIST1H2AD ▸ GNB2 ▸ PTPN1 ▸ GNG8 ▸ IGHG4 ▸ GNAI3 ▸ GNG2 ▸
PLCZ1 ▸ IGLC3 ▸ CRKL ▸ ATPIF1 ▸ HNRNPUL1 ▸ BCAR1 ▸ IGHE ▸
ENY2 ▸ GNG11 ▸ PIP5K1A ▸ MRPS14 ▸ PGAM1 ▸ PON2 ▸ RPL23 ▸
ALDOA ▸ TEK ▸ SNRPF ▸ ACTG2 ▸ FGA ▸ DNM1L ▸ SQSTM1 ▸
HNRNPA1 ▸ HRNR ▸ NGFB ▸ HIST3H2BB ▸ H2BFS ▸ NPHS2 ▸ WDR6 ▸
MRPS25 ▸ CD3Z ▸ EPHB1 ▸ HIST1H2BD ▸ SGK2 ▸ HNRNPU ▸ FUS ▸
IL4R ▸ INSRR ▸ MAP2K2 ▸ VEGF ▸ RPS2 ▸ ACTBL2 ▸ SSR1 ▸
ILF2 ▸ PAICS ▸ APLP2 ▸ GNG7 ▸ RPS24 ▸ HIST1H2AG ▸ HNRNPH1 ▸
RPS10 ▸ PGAM4 ▸ DHX15 ▸ HIST1H2AB ▸ EIF5AL1 ▸ SEMG1 ▸ EIF5A2 ▸
HIST1H2BO ▸ GNAI2 ▸ TYROBP ▸ RPSA ▸ EEF1A1 ▸ PRDX6 ▸ EEF2 ▸
PIK3C2B ▸ HIST1H2BK ▸ PPP1CB ▸ SLC25A3 ▸ NKRF ▸ HIST1H1T ▸ YWHAH ▸
HIST1H2AC ▸ SYNCRIP ▸ GNG3 ▸ RASD2 ▸ SNRPD3 ▸ EPS8 ▸ PIK3AP1 ▸
HIST1H2AJ ▸ IGKC ▸ ITIH1 ▸ NPM1 ▸ HNRNPAB ▸ KLRD1 ▸ PDE4D ▸
RPS3 ▸ RPL28 ▸ IL2RB ▸ HIST1H2AH ▸ GNAQ ▸ GNG13 ▸ ITGAV ▸
FGB ▸ DHX9 ▸ IGLC2 ▸ IFNGR1 ▸ HIST3H2A ▸ MOV10 ▸ FLT3 ▸
IL1RAP ▸ FCER1A ▸ MRPS27 ▸ MYL6 ▸ CBLC ▸ LAT ▸ C14orf166 ▸
PCBP2 ▸ PIP5K1C ▸ MYH14 ▸ OCRL ▸ HLA-E ▸ SH2D2A ▸ SLC25A4 ▸
GFRA1 ▸ ILF3 ▸ FGG ▸ IL2RG ▸ ELAVL1 ▸ PIP4K2C ▸ INPP5E ▸
HIST1H2BJ ▸ IGHG2 ▸ PCID2 ▸ ARHGEF1 ▸ PLCB3 ▸ INS-IGF2 ▸ ERH ▸
MRAS ▸ IGF2BP3 ▸ PPP1CC ▸ TRIM21 ▸ RUVBL2 ▸ TRA@ ▸ NR3C1 ▸
HIST1H4A ▸ IGKV4-1 ▸ MATR3 ▸ HIST1H2BL ▸ PABPC4 ▸ FLNB ▸ CSF2RA ▸
HNRNPC ▸ KLB ▸ RPLP0 ▸ MRPS23 ▸ HIST1H2BH ▸ RPS20 ▸ FTL ▸
VAV3 ▸ PCBP1 ▸ CANX ▸ PRKRA ▸ TUBA1C ▸ IGLC7 ▸ HLA-DRB1 ▸
EEF1A1P5 ▸ HNRNPA0 ▸ SH3KBP1 ▸ ANXA2 ▸ APPL1 ▸ STAU1 ▸ RPS11 ▸
HIST1H2BM ▸ NEDD9 ▸ IL23R ▸ XRN2 ▸ YWHAG ▸ HLA-DRA ▸ PGF ▸
FCGR3B ▸ MRPS34 ▸ HNRNPA2B1 ▸ HIST1H1A ▸ IGF2BP2 ▸ WDR5 ▸ GNG5 ▸
MRPS18B ▸ MYH10 ▸ PIK3R4 ▸ DDX3Y ▸ NRAS ▸ RPS18 ▸ TUBA1A ▸
DNAJB11 ▸ GNG10 ▸ PGAM2 ▸ PLCB2 ▸ RPL22 ▸ PPP1CA ▸ YWHAE ▸
PABPC1 ▸ PLCD3 ▸ DNAJB6 ▸ MRPS28 ▸ ATP1A1 ▸ HNRNPDL ▸ HIST2H2AA3 ▸
PLCD4 ▸ GNGT2 ▸ EFNA1 ▸ PDGFRA ▸ CPSF1 ▸ MASP1 ▸ CTNNA1 ▸
RTCB ▸ TUBB ▸ MYO1C ▸ LGALS3BP ▸ HIST1H2BB ▸ IGF2BP1 ▸ HNRNPL ▸
DGKZ ▸ SHANK3 ▸ GNB3 ▸ PLCB4 ▸ SHC3 ▸ PDPK1 ▸ F11R ▸
RPS12 ▸ KLRC2 ▸ PTMA ▸ CSF2RB ▸ GNB1 ▸ LRPPRC ▸ AMBP ▸
MYH9 ▸ MRPS26 ▸ PPIA ▸ ITGB3 ▸ TRIM24 ▸ FBL ▸ TUBB4B ▸
GNG4 ▸ ADAP1 ▸ PGR ▸ KLRK1 ▸ EFNB2 ▸ STAT5B ▸ HIST2H2BF ▸
TPI1 ▸ ANGPT1 ▸ ZMYM2 ▸ LDHB ▸ SHC2 ▸ UNC5B ▸ ATP1A3 ▸
SEMG2 ▸ YWHAQ ▸ GNAO1 ▸ GNA14 ▸ CALR ▸ FGFR1OP ▸ HNRNPK ▸
POTEKP ▸ HSP90AB1 ▸ RUVBL1 ▸ RHOG ▸ YBX3 ▸ CSF1R ▸ TIMM50 ▸
PIK3R6 ▸ PGK1 ▸ EIF2AK1 ▸ IL3RA ▸ FCER1G ▸ EIF5A ▸ FCGR1A ▸
RPLP1 ▸ ADAR ▸ ITGB2 ▸ IGHG1 ▸ GNB5 ▸ HIST1H2BN ▸ UFD1L ▸
SPTA1 ▸ IL5RA ▸ HNRNPD ▸ PIK3R5 ▸ BASP1 ▸ ENO1 ▸ DHX30 ▸
IGLC1 ▸ HIST2H2AA4 ▸ PHLDA1 ▸ RALY ▸ PLCE1 ▸ RPS5 ▸ IL1R1 ▸
VARS2 ▸ PTCD3 ▸ S100A10 ▸ RBMX ▸ DDX3X ▸ HCST ▸ HLA-B ▸
PCBP3 ▸ GSN ▸ PIK3C2G ▸ ZAP70 ▸ FLT1 ▸ ALYREF ▸ MDH2 ▸
MRPS17 ▸ JUP ▸ GNB4 ▸ TRB@ ▸ FCGR3A ▸ HLA-A ▸ GNAI1 ▸
YWHAZ ▸ SLC25A31 ▸ CD247 ▸ UBC ▸ CKB ▸ H2AFJ ▸ PIP4K2A ▸
ACTA2 ▸ AIFM1 ▸ GABRB1 ▸ HNRNPA3 ▸ MS4A2 ▸ LAT2 ▸ NBPF8 ▸
HNRNPR ▸ TIAM2 ▸ GRIN2B ▸ EDG1 ▸ FGFR1OP2 ▸ HIST2H2BE ▸ PLCD1 ▸
GH1 ▸ NPHS1 ▸ UPF1 ▸ ABI1 ▸ CUX1 ▸ PIK3R3 ▸ DLG1 ▸
DNAJA1 ▸ SLC9A3R1 ▸ DDX5 ▸ MRPS22 ▸ IGLC6 ▸ NEFH ▸ RRAS2 ▸
IGKV1-5 ▸ AMPH ▸ GNG12 ▸ GHR ▸ ITK ▸ KHDRBS1 ▸ MIF ▸
RPS4X ▸ IGHG3 ▸ B2M ▸ AP1M2 ▸ GNGT1 ▸ HNRNPH2 ▸ EEF1A2 ▸
PRKCI ▸ EPHB4 ▸ PLCB1 ▸ PIK3C2A ▸ SYNJ2 ▸ MARCKS ▸ HIST1H2AE ▸
IL12RB1 ▸ RPLP0P6 ▸ VAV2 ▸ HNRNPF ▸ GNA11 ▸ TRAT1 ▸ EPB41L1 ▸
SLC25A5 ▸ SMO ▸ SOS1 ▸ TXK ▸ MRPL12 ▸ ATP5B ▸ KIRREL ▸
TREM2 ▸ YES1 ▸ UBTF ▸ FRS2 ▸ PABPN1 ▸ ATR ▸ IL23A ▸
Il7r ▸ SYNJ1 ▸ INPP5B ▸ PIK3R2 ▸ GNA15 ▸ RASGRP3 ▸ PTBP1 ▸
CCT5 ▸ VLDLR ▸ HNRNPH3 ▸ CD80 ▸ CCAR2 ▸ KL ▸ FIGF ▸
FES ▸ ATXN2L ▸ TUBA4A ▸
Data information
Please see the Gene Interactions Track Manual.