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E2F1 — MTOR
Text-mined interactions from Literome
Real et al., PloS one 2011
:
The
activation of cell growth and
mTORC1 by
E2F1 is dependent on both E2F1 's ability to bind DNA and to regulate gene transcription, demonstrating that a gene induction expression program is required in this process ... The
effect of
E2F1 on the activation of
mTORC1 does not depend on Akt ... Immunolocalization studies demonstrate that
E2F1 induces the translocation of
mTORC1 to the late endosome vesicles, in a mechanism dependent of leucine
Bhattacharya et al., Cancer Biol Ther 2012
(Stomach Neoplasms) :
Here, we tested the hypothesis that the dual
PI3K/mTOR inhibitor, PI103, could
synergize with the chemotherapeutic agent, 5-fluorouracil ( 5-FU ) by inhibiting
E2F1 , thymidylate synthase ( TS ) and enhancing DNA damage