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EGR1 — SIRT1

Text-mined interactions from Literome

Pardo et al., J Biol Chem 2011 : In this report, we unravel a mechanism triggered by mechanical stretch of skeletal muscle cells that leads to an EGR1 dependent transcriptional activation of the Sirt1 gene
Pardo et al., Aging 2012 (Mechanotransduction, Cellular) : An autoregulatory loop reverts the mechanosensitive Sirt1 induction by EGR1 in skeletal muscle cells ... At the core of this mechanism, transcriptional activation of SIRT1 by the early growth response protein EGR1 results in increased MnSOD activity through the activation of Sod2 by SIRT1/FOXO pathway ... In this report, we show experimental evidence that ; a ) EGR1 and SIRT1 proteins physically interact at the time of maximal Sirt1 induction, b ) SIRT1 has a negative effect on the activation of the Sirt1 promoter by EGR1