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Chau et al., Proc Natl Acad Sci U S A 2010
(Obesity) :
Activation of AMPK and SIRT1 by FGF21 in adipocytes enhanced mitochondrial oxidative capacity as demonstrated by increases in oxygen consumption, citrate synthase activity, and induction of key metabolic genes
Vilà-Brau et al., J Biol Chem 2011
:
This effect was blunted by SirT1 ( sirtuin 1 ) RNAi, so we propose a SirT1 dependent mechanism for FGF21 induction by acetoacetate ... This mechanism could be physiologically relevant, because fasting mediated induction of liver FGF21 was dependent on SirT1 activity in vivo