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CREB5 — MTOR
Text-mined interactions from Literome
Ohmae et al., J Biol Chem 2006
:
Although these were previously shown to activate Ca ( 2+ ) /cAMP-response element binding protein ( CREB ) -dependent transcription, we here show that CL1 and CL2 were unable to significantly phosphorylate CREB Ser-133 and rather inhibited CRE dependent gene expression by a dominant mechanism that bypassed
CREB and was
mediated by phosphorylated
TORC2
Wang et al., J Immunol 2011
(Inflammation) :
At the transcriptional level,
mTORC1 inhibition
reduced the DNA binding of
CREB and this effect was reversed by GSK3 inhibition
Zhong et al., PloS one 2012
(Inflammation...) :
This study indicates that resveratrol inhibited LPS induced proinflammatory enzymes and proinflammatory cytokines via down-regulation phosphorylation of NF-?B,
CREB and MAPKs family in a
mTOR dependent manner
Palaniappan et al., Mol Endocrinol 2012
:
Furthermore, the pharmacological inhibition of
mTORC1 or ribosomal protein S6 kinase 1 signaling
prevented the LH/hCG induced phosphorylation of
CREB