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IL12B — MTOR

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → mTOR (MTOR) (modification, activates) Kusaba et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Kusaba et al., J Biol Chem 2005 : IL-12 induced phosphorylation of Stat3 on Ser-727 was affected by rapamycin, which may be due to the effect of rapamycin on the IL-12 induced interaction between mammalian target of rapamycin (mTOR) and Stat3
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : Rapamycin, an inhibitor of mTOR, enhanced IL-12 production in LPS stimulated DCs, whereas the activation of mTOR by lentivirus mediated transduction of a constitutively active form of Rheb suppressed the production of IL-12
Cheekatla et al., Med Microbiol Immunol 2012 (Leishmaniasis, Visceral) : We show for the first time that in THP-1 derived macrophages and human monocytes, mTOR inhibition by rapamycin reversed L. donovani induced IL-12 and IL-10 modulation