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MTOR — PIK3C3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nobukuni et al., Proc Natl Acad Sci U S A 2005
:
Unexpectedly, we found that a major pathway by which amino acids control mTOR signaling is distinct from that of insulin and that, instead of signaling through components of the insulin/class 1 PI3K pathway, amino acids
mediate mTOR activation by signaling through class 3 PI3K,
hVps34
Xu et al., J Biol Chem 2011
:
Amino acid- and glucose induced PLD and
mTORC1 activity were also
dependent on the GTPases RalA and ARF6 and the type III phosphatidylinositol-3-kinase
hVps34
Yoon et al., J Cell Biol 2011
:
Furthermore, amino acids stimulate PLD1 translocation to the lysosomal region where
mTORC1 activation occurs in an
hVps34 dependent manner, and this translocation is necessary for mTORC1 activation