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ADIPOQ — INS

Text-mined interactions from Literome

Bogan et al., J Cell Biol 1999 : Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme
Halleux et al., Biochem Biophys Res Commun 2001 (Obesity) : apM1 gene expression was also negatively regulated by glucocorticoids and positively by insulin and IGF-1
Maeda et al., Nat Med 2002 (Insulin Resistance) : Our results indicate that adiponectin/ACRP30 deficiency and high TNF-alpha levels in KO mice reduced muscle FATP-1 mRNA and IRS-1 mediated insulin signaling, resulting in severe diet induced insulin resistance
Kita et al., Biochem Biophys Res Commun 2005 : Adiponectin , an adipose tissue-specific plasma protein, is involved in insulin sensitizing and has anti-atherosclerotic properties
Bose et al., J Biol Chem 2005 : The v-SNARE Vti1a regulates insulin stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes
Dullaart et al., Scand J Clin Lab Invest 2005 (Diabetes Mellitus, Type 2) : Adiponectin expression in adipose tissue is up-regulated by peroxisome proliferator activated receptor ( PPAR)-gamma agonist treatment and its plasma level may be affected by insulin
Staiger et al., J Clin Endocrinol Metab 2005 : Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis
Westerbacka et al., Diabetologia 2006 (Body Weight...) : Insulin significantly increased expression of ` insulin-sensitivity genes ' SLC2A4, PPARG, PPARGC1A and ADIPOQ in the insulin-sensitive group, while only expression of PPARG and PPARGC1A was increased in the insulin-resistant group
Clarke et al., Biochem Biophys Res Commun 2006 : Collectively, these data implicate both Arf6 and Rab11 as crucial mediators of constitutive and insulin stimulated secretion of ACRP30 and further suggest that recycling endosomes may play a central role in this process
Zeng et al., Life Sci 2007 (Body Weight) : Adiponectin reportedly reduces insulin-resistance
Zhang et al., Eur J Endocrinol 2008 (Genetic Predisposition to Disease...) : Adiponectin is the most abundant adipocytokine and may play a role in the regulation of insulin sensitivity and IR in PCOS
Okamoto et al., Diabetologia 2008 : Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration ... Adiponectin significantly stimulated insulin secretion from pancreatic islets to approximately 2.3-fold the baseline value in the presence of a glucose concentration of 5.6 mmol/l
Sonoda et al., Endocrinology 2008 : Adiponectin and leptin, and adipocyte-specific genes of adiponectin, leptin, and PPAR-gamma were detected in culture assembly, whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent TNF-alpha ( 2 nm ) increased and decreased, respectively, all of their displays
Li et al., J Endocrinol Invest 2010 : Effect of short hairpin RNA mediated adiponectin/Acrp30 down-regulation on insulin signaling and glucose uptake in the 3T3-L1 adipocytes
Lee et al., Metabolism 2011 (Insulin Resistance) : Adiponectin stimulates insulin secretion by enhancing exocytosis of insulin granules and upregulating the expression of the insulin gene ; however, this effect depends on the prevailing glucose concentration and status of insulin resistance
Rao et al., Diabetes Obes Metab 2012 (Diabetes Mellitus, Type 2...) : Adiponectin upregulates PPAR? expression, insulin content and insulin secretion through PPAR? dependent mechanisms
Scherer et al., J Biol Chem 1995 : Like adipsin, secretion of Acrp30 is enhanced by insulin , and Acrp30 is an abundant serum protein