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ATF2 — INS
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ban et al., Diabetes 2000
:
Furthermore, when transfected into rat primary cultured islets,
ATF-2 enhanced glucose induced
insulin promoter activity, whereas cAMP response element binding protein ( CREB ) repressed it ... These results suggest a mechanism in which
ATF-2 regulates
insulin gene expression in pancreatic beta-cells, with the transcriptional activity of ATF-2 being increased by an elevated concentration of calcium ions
Ouwens et al., EMBO J 2002
(MAP Kinase Signaling System) :
Here, we show that in fibroblasts,
insulin , epidermal growth factor (EGF) and serum
activate ATF2 via a so far unknown two-step mechanism involving two distinct Ras effector pathways : the Raf-MEK-ERK pathway induces phosphorylation of ATF2 Thr71, whereas subsequent ATF2 Thr69 phosphorylation requires the Ral-RalGDS-Src-p38 pathway
Keeton et al., Endocrinology 2005
(Carcinoma, Hepatocellular...) :
In the present work,
insulin 's regulation of expression of
activating transcription factor 3 ( ATF-3 ), the putative transcription factor proline-rich induced protein (Pip)92, and insulin-inducible gene-1 (Insig-1) ( an ER resident protein involved in regulation of sterol-responsive element binding protein 1 activation ) have been examined in a liver derived cell line ( rat H4IIE hepatoma cells )
Baan et al., Mol Endocrinol 2006
:
Insulin activates
ATF2 by phosphorylation of Thr69 and Thr71 via a two-step mechanism, in which ATF2-Thr71 phosphorylation precedes the induction of ATF2-Thr69+71 phosphorylation by several minutes ... Because JNK is also capable of phosphorylating ATF2, we assessed the involvement of JNK, ERK1/2 and p38 in the
insulin induced two-step
ATF2 phosphorylation in JNK expressing A14 fibroblasts and 3T3L1-adipocytes ... We conclude that sequential activation and nuclear appearance of ERK1/2 and JNK, rather than p38, underlies the two-step
insulin induced
ATF2 phosphorylation in JNK expressing cells
Hay et al., Biochim Biophys Acta 2007
:
ATF-2 stimulates the human
insulin promoter through the conserved CRE2 sequence
Han et al., J Biol Chem 2011
:
ATF2 interacts with beta-cell enriched transcription factors, MafA, Pdx1, and beta2, and
activates insulin gene transcription ...
ATF2 also interacted with Pdx1 and Beta2, and co-expression of ATF2, MafA, Pdx1, and Beta2
resulted in a synergistic activation of the
insulin promoter