Ducobu et al., Rev Med Brux 2005
:
CB1 blockade by a specific inhibitor ( rimonabant ) decreases food intake and weight in animal studies and increases adiponectin and insulin sensitivity
Ducobu et al., J Pharm Belg 2005
(Obesity) :
CB1 blockade by a specific inhibitor ( rimonabant ) decreases food intake and weight in animal studies and increases adiponectin and insulin sensitivity
Matias et al., J Clin Endocrinol Metab 2006
(Diabetes Mellitus, Type 2...) :
CB(1) receptor stimulation increases lipid droplets and decreases adiponectin expression in adipocytes, and it increases intracellular calcium and insulin release in RIN-m5F beta-cells kept in high glucose
Li et al., Islets 2010
(Hyperglycemia...) :
We have therefore investigated cannabinoid receptor expression by mouse islet ß-and a-cells and the effects of selective receptor agonists on cyclic AMP and calcium levels, and on dynamic insulin secretory responses
Liu et al., Gastroenterology 2012
(Fatty Liver...) :
Endocannabinoids contribute to diet induced insulin resistance in mice via hepatic CB(1) mediated inhibition of insulin signaling and clearance