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Liao et al., J Neurochem 2000 : The postsynaptic density protein PSD-95 differentially regulates insulin- and Src mediated current modulation of mouse NMDA receptors expressed in Xenopus oocytes
Lee et al., J Biol Chem 2005 : This insulin induced increase in the PSD-95 protein expression was inhibited by the tyrosine kinase inhibitor, AG1024, phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin, translational inhibitors, anisomycin and rapamycin, but not by LY303511 ( an inactive analogue of LY294002 ), and transcriptional inhibitor, actinomycin D, suggesting that insulin regulates the translation of PSD-95 by activating the receptor tyrosine kinase-PI3K-mammalian target of rapamycin (mTOR) signaling pathway ... A similar insulin induced increase in the PSD-95 protein expression was detected after stimulation of the synaptic fractions isolated from the hippocampal neurons ... Taken together, these findings suggest that activation of the PI3K-Akt-mTOR signaling pathway is essential for the insulin induced up-regulation of local PSD-95 protein synthesis in neuronal dendrites and indicate a new molecular mechanism that may contribute to the modulation of synaptic function by insulin in hippocampal area CA1