◀ Back to INS

IGF2 — INS

Text-mined interactions from Literome

Gu et al., Biol Reprod 1999 : Insulin-like growth factor (IGF)-I and IGF-II play a number of important roles in growth and differentiation, and IGF binding proteins ( IGFBPs ) modulate IGF biological activity
Katz et al., J Clin Endocrinol Metab 1999 (Hyperinsulinism) : Our data suggest that IGF inhibition of insulin secretion does not require an intact SUR
Tomizawa et al., J Biol Chem 2000 : A mechanism for insulin inhibition of insulin-like growth factor binding protein-1 transcription
Leinsköld et al., J Endocrinol 2000 : In contrast, IGF-I caused a marked reduction of insulin and IAPP secretion
Mounier et al., Mol Cell Endocrinol 2001 : Analysis of downstream events showed that hGrb10zeta over-expression specifically inhibits insulin stimulated glycogen synthase ( GS ) activity and glycogen synthesis without affecting insulin induced IRS1/2 phosphorylation, PI3-kinase activation, insulin like growth factor binding protein-1 ( IGFBP-1 ) mRNA expression, and ERK1/2 MAP kinase activity
Osipo et al., Exp Cell Res 2001 : Receptor neutralization studies and measurements of insulin receptor substrate 1 phosphorylation confirm that the enhanced growth of D9 cells is due to increased stimulation of the IGF-I and insulin receptors by IGF-II
Rocha et al., Curr Eye Res 2000 (Diabetes Mellitus, Experimental) : Functional studies demonstrated that insulin induced a dose dependent phosphorylation of the insulin receptor, IGF-1R , insulin receptor substrates-1 and -2, Shc, and STAT-1
Patel et al., J Biol Chem 2002 : Insulin regulation of insulin-like growth factor binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity
Li et al., Zhonghua Yu Fang Yi Xue Za Zhi 1999 (Fetal Diseases...) : Malnutrition during rat fetal development could cause inhibition of expression of insulin gene, but no obvious effects on the expression of glucagon and IGF-II genes
Mur et al., Diabetes 2002 : In addition, the lack of IGF-IR in brown adipocytes resulted in a higher mitogenic response ( DNA synthesis, cell number, and proliferating cell nuclear antigen expression ) to insulin than wild-type cells
Wang et al., Oncogene 2002 (Colonic Neoplasms) : Cell cycle re-entry required exogenous growth factor activation of the IGF-IR by insulin or IGF-I
Davidson et al., Biol Reprod 2002 : The objectives of this study were to determine, first, if estradiol, insulin , and/or FSH affect steroid production by equine granulosa cells ( experiment 1 ) and, second, if the components of the IGF system are produced by equine granulosa cells in culture as well as whether estradiol, insulin, and/or FSH affects IGF and/or IGF binding protein ( IGFBP ) production by equine granulosa cells ( experiment 2 ) ... Insulin and FSH inhibited ( P < 0.05 ) IGF-II production by granulosa cells of large and medium but not of small follicles ; estradiol was without effect
Vatten et al., Pediatrics 2002 (Birth Weight) : If intrauterine growth is related to the risk of developing adult diseases, IGF-I , IGFBP-1, and leptin may be involved in the underlying processes.1131-1135 insulin like growth factors, leptin, umbilical cord plasma, birth weight
Spicer et al., Domest Anim Endocrinol 2002 : Insulin , IGF-I and FSH also increased ( P < 0.05 ) granulosa cell numbers and progesterone production but their maximal effects were less ( i.e., < 4-fold increase ) than their effects on estradiol production
Cormont et al., Eur J Biochem 1992 : In a similar fashion, polymyxin B inhibited the insulin induced increase in IGF II binding to adipocytes
Giudice et al., J Clin Endocrinol Metab 1992 : Since insulin-like growth factors (IGFs) and IGF binding proteins ( IGFBPs ) are believed to be involved in endometrial differentiation, and insulin regulates IGFBP production in a variety of cells, we have investigated the modulatory roles of EGF, progesterone, and insulin on IGFBP secretion by long term cultures of human endometrial stromal cells
Kooijman et al., Endocrinology 1992 : The specific binding of [ 125I ] IGF-I to monocytes could be completely inhibited by IGF-II and insulin , but higher doses of these peptides were needed than of IGF-I
Cissewski et al., Receptor 1992 : 125I-IGF-II binding also was inhibited significantly by insulin , suggesting that much or all of the IGF-II was bound to the type-I IGF receptor
Stout et al., Eur J Epidemiol 1992 (Arteriosclerosis...) : The proliferative effects of insulin are mediated by the insulin-like growth factor receptor and hence may not be impaired in states of insulin resistance
Valverde et al., Mol Biol Cell 2004 : However, the survival effect of insulin on IGF-IR ( -/- ) brown adipocytes was elicited even in the absence of phosphatidylinositol 3-kinase/Akt signaling
Choi et al., J Biochem Mol Biol 2004 : The acid-labile subunit (ALS) is known to interact with the IGF binding protein ( IGFBP ) in the presence of insulin-like growth factors (IGFs)
Marchand et al., Mol Pharmacol 2005 : 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin
Hartnell et al., J Immunol 2004 (Nasal Polyps) : Insulin-like growth factor-2 (IGF-2) was identified in these HPLC fractions, and the basophil stimulating activity was inhibited by an anti-IGF-2 neutralizing Ab. Recombinant IGF-2 induced a substantial shape change response in basophils, but not eosinophils, neutrophils, or monocytes
El Yafi et al., Clin Exp Immunol 2005 (Crohn Disease...) : The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGF receptor ( IGF-1R )
Guo et al., Endocrinology 2005 (Glucose Intolerance) : Compared with GHR ( -/- ) alone, IGF-I overexpression on a GHR ( -/- ) background caused no change in the diminished blood glucose and serum insulin levels, pancreatic insulin contents, and insulin tolerance but improved glucose tolerance and insulin secretion
Moon et al., Int J Cancer 2006 (Carcinoma, Non-Small-Cell Lung...) : Insulin-like growth factor binding protein-3 ( IGFBP-3 ) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor
Li et al., Endocrinology 2005 : At concentrations 1-5 nm or greater, insulin dose-dependently enhanced the tyrosine phosphorylation of IGF-IRbeta , and this was inhibited by IGF-IR neutralizing antibody ... We conclude that : 1 ) insulin at physiological concentrations selectively activates IR signaling in bAECs ; 2 ) bAECs express IGF-IR and insulin/IGF-I hybrid receptors in addition to IR ; 3 ) high concentrations of insulin ( > or=1-5 nM ) activate IGF-IR and hybrid receptors as well as IR ; and 4 ) this crossover activation can confound interpretation of studies of insulin action in ECs when high insulin concentrations are used
Wang et al., Am J Physiol Endocrinol Metab 2006 : We conclude that in vivo endothelial cells rapidly take up and concentrate insulin relative to plasma and muscle interstitium and that IGF-IR , like IR, may mediate insulin transit through endothelial cells in a process involving caveolae
Thraikill et al., J Clin Invest 1990 : Differential regulation of insulin-like growth factor binding protein secretion from human decidual cells by IGF-I, insulin , and relaxin
Rose et al., Oncogene 2007 (Cell Transformation, Viral...) : The expression of the insulin receptor (IR) was strongly induced in latently infected E-DMVEC, whereas the expression levels of the IGF-IR remained unchanged
McGrath et al., Endocrinology 1991 : The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins
Orlowski et al., Mol Endocrinol 1991 (Liver Neoplasms, Experimental) : Insulin rapidly inhibits insulin-like growth factor binding protein-1 gene expression in H4-II-E rat hepatoma cells
Eggo et al., Growth Factors 1991 : Thyrotropin inhibits while insulin , epidermal growth factor and tetradecanoyl phorbol acetate stimulate insulin-like growth factor binding protein secretion from sheep thyroid cells
Denley et al., Mol Cell Biol 2007 : Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor activated insulin receptors
Bezchlibnyk et al., Brain Res 2007 : Insulin-like growth factors (IGFs) regulate cellular proliferation and death, and their bioactivity is controlled by IGF binding proteins ( IGFBPs )
Oku et al., Anticancer Res 1991 (Carcinoma, Squamous Cell...) : These data suggest that IGF-I, IGF-II and insulin, as well as EGF and TGF-alpha, are important mitogens for human esophageal cancer cells and that effects of IGFs and insulin are mediated predominantly via IGF-I receptors
Fulzele et al., J Biol Chem 2007 : Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action
Zvibel et al., Mol Cell Biol 1991 (Carcinoma, Hepatocellular...) : Transcriptionally, IGF II was regulated by the additive effects of insulin , glucagon, and growth hormone in combination with heparin ; TGF beta was regulated primarily by the synergistic effects of insulin and growth hormone in combination with heparin
Stuart et al., J Clin Endocrinol Metab 1991 : Binding of [ 125I ] IGF-I to mononuclear cells was inhibited by both unlabeled IGF-I and insulin , insulin being 200-fold less potent than IGF-I
Bäck et al., Growth Horm IGF Res 2009 : In PA both the IR and the IGF-IR was phosphorylated by their own ligand at 1 nM and in dPA the activation of both receptors was stimulated by IGF-I, but not insulin , at 1 nM
Kwon et al., Cancer Res 2009 (Adenocarcinoma...) : Furthermore, we also showed that insulin receptor substrate (IRS)-2 , but not IRS-1, is involved in regulation of IGF-IR expression, which is most likely not transcriptional control
Iñiguez et al., Growth Horm IGF Res 2009 : IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children
Kimura et al., Journal of clinical biochemistry and nutrition 2010 : Effect of paraquat induced oxidative stress on insulin regulation of insulin-like growth factor binding protein-1 gene expression
Yehezkel et al., Diabetologia 2010 : Confocal imaging experiments showed that insulin glargine, but not regular insulin induced IGF-IR internalisation similarly to IGF-I ... Our data indicate that insulin glargine and insulin detemir display atypical signalling activities that differ from those elicited by regular insulin and involve activation of the anti-apoptotic IGF-IR
Maor et al., Am J Physiol Endocrinol Metab 2011 : Additionally, insulin induced both GLUT4 and IGF-IR gene expression and improved condylar growth in insulin receptor knockout mice derived MC
Corvera et al., J Biol Chem 1990 : The effects of insulin on the subcellular distribution of the heavy chain of clathrin and on the insulin-like growth factor II (IGF-II) mannose 6-phosphate receptor were investigated in isolated rat adipocytes
Gansler et al., In Vitro Cell Dev Biol 1990 : These data are consistent with regulation of tubular epithelial proliferation by IGF-1, insulin, and EGF and suggest that the mitogenic activity of both insulin and IGF-1 is mediated by the type 1 IGF receptor
Eriksson et al., Biochem J 1990 : The insulin-like effect of growth hormone on insulin-like growth factor II receptors is opposed by cyclic AMP
Minshall et al., Domest Anim Endocrinol 1990 : Receptor cross linking analysis using disuccinimidyl suberate was performed on near-confluent satellite cell cultures incubated with [ 125I ] IGF-I in the presence or absence of 1 X 10 ( -7 ) M IGF-I, IGF-II, or insulin
Kalla Singh et al., Growth Factors 2011 (Breast Neoplasms...) : Since IGF-II activates the insulin receptor (INSR) , we propose that the INSR signaling is also activated in this system
Zhang et al., Cell Biochem Funct 2012 : Subsequently, we show that although both insulin and IGF-1 promote osteoblast differentiation and mineralization in vitro, IGF-1 , but not insulin, can induce osteoblast proliferation
Appleman et al., Mol Cancer Res 2012 : Interestingly, we find that activation of PI3K/AKT signaling occurs downstream of MAP-ERK kinase ( MEK ), and is dependent on the autocrine activation of the insulin-like growth factor (IGF) receptor ( IGF1R ) by IGF2
Yamada et al., Int J Hematol 2013 (Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) : Insulin-like growth factor-1 (IGF-1) is known to be a major growth factor with effects on various cell types, including hematopoietic cells, as well as neoplasms, and is regulated by IGF binding proteins ( IGFBPs )
King et al., Journal of ovarian research 2013 : Although insulin and IGF are potent proliferative factors for the ovarian surface epithelium and IGF is required for follicle development, increased insulin and IGF activity are correlated with at least two gynecologic conditions : polycystic ovary syndrome and epithelial ovarian cancer
Kjaer-Sorensen et al., J Biol Chem 2013 : Pregnancy associated plasma protein-A ( PAPP-A ) is a large metalloproteinase specifically cleaving insulin-like growth factor (IGF) binding proteins, causing increased IGF bioavailability and, hence, local regulation of IGF receptor activation
Lauterio et al., Endocrinology 1990 : Divergent effects of insulin on insulin-like growth factor-II gene expression in the rat hypothalamus
De Vroede et al., J Clin Invest 1986 : By contrast, in fibroblast monolayers, IGF-I binding was minimally inhibited by insulin or hybrid molecules, suggesting predominant binding to the type II IGF receptor
Conover et al., J Clin Invest 1989 (Carcinoma, Hepatocellular...) : Insulin , epidermal growth factor, platelet derived growth factor, and progesterone had no effect on IGF binding activity in fibroblast media
Froger-Gaillard et al., Endocrinology 1989 : Insulin ( 5 micrograms/ml ) increased IGF-I production by a factor of 2.6, but increased IGF-II production by a factor of only 1.4
Keller et al., Acta Endocrinol (Copenh) 1989 (Carcinoma, Hepatocellular...) : As the liver is the major site of insulin degradation, we studied insulin degradation by HepG2 cells in the presence of IGF ... Thus, IGF-I and IGF-II inhibit insulin degradation most likely by competing for binding at insulin binding sites of liver cells ... Thus, IGF-I and IGF-II inhibit insulin degradation most likely by competing for binding at insulin binding sites of liver cells
Rieu et al., J Clin Endocrinol Metab 1985 (Diabetes Mellitus, Type 1) : The results clearly reflect the role of insulin and nutritional factors in the control of IGF levels
Guler et al., Proc Natl Acad Sci U S A 1989 : Blood glucose and fasting insulin levels remained within normal limits and IGF-II levels were suppressed
Beguinot et al., Endocrinology 1989 : In undifferentiated L6 myoblasts, stimulation by either insulin or IGF-I, but not IGF-II, led to a 3- to 5-fold increase in phosphorylation of insulin and IGF receptor beta-subunits and the appearance of a 175,000 mol wt ( Mr ) phosphoprotein ( pp175 ) ... In undifferentiated L6 myoblasts, stimulation by either insulin or IGF-I, but not IGF-II , led to a 3- to 5-fold increase in phosphorylation of insulin and IGF receptor beta-subunits and the appearance of a 175,000 mol wt ( Mr ) phosphoprotein ( pp175 )
Rodeck et al., J Cell Biochem 1987 : This result indicates that the type I IGF receptor mediated growth stimulation not only by IGF-I but also by insulin
Lönnroth et al., J Biol Chem 1988 : N6-Monobutyryl-cAMP and 8-bromo-cAMP were equally potent in reducing IGF-II binding in the absence of insulin and inhibited maximal insulin stimulated IGF-II binding by 60 and 30 %, respectively
Kadowaki et al., J Biol Chem 1986 : Thus, this study provides evidence that IGF-I and insulin act mostly through their own ( homologous ) receptors and that IGF-II acts by cross reacting with both type I IGF and insulin ( heterologous ) receptors in causing rapid alterations in cytoskeletal structure
Misra et al., J Clin Endocrinol Metab 1986 : Unlike IGF-II binding to the classical type II IGF receptor, [ 125I ] IGF-II binding to IM-9 cells was potently inhibited not only by unlabeled IGF-II, but also by insulin ( 50 % inhibition of binding at 2.5 and 1.5 nM, respectively )
Lönnroth et al., Proc Natl Acad Sci U S A 1987 : Regulation of insulin-like growth factor II receptors by growth hormone and insulin in rat adipocytes ... However, the maximal incremental effect of insulin on IGF-II binding was reduced approximately 27 % by hypophysectomy
Bolinder et al., J Clin Endocrinol Metab 1987 (Diabetes Mellitus, Type 2) : In contrast, IGF-I inhibited [ 125I ] insulin binding with a molar potency 1600 times lower than that of native insulin
Corvera et al., J Biol Chem 1988 (Liver Neoplasms, Experimental) : Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells ... Insulin caused a rapid, dose dependent increase in the binding of 125I-insulin-like growth factor-II (IGF-II) to the surface of cultured H-35 hepatoma cells
Appell et al., J Biol Chem 1988 : Differences in the mechanism of insulin action on insulin-like growth factor II receptors and glucose transporters ... 1 ) Insulin increases the steady state number of cell surface IGF-II receptors by 7-13-fold without affecting receptor affinity ; however, insulin stimulates glucose transport activity by 25-40-fold ... However, in response to insulin , the number of plasma membrane IGF-II receptors increases only approximately 1.4-fold while the number of glucose transporters increases approximately 4.5-fold
Oka et al., J Biol Chem 1985 : Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process ... Using the above methodology, it is shown that acute insulin action : 1 ) increases the steady state number of cell surface IGF-II receptors ; 2 ) increases the number of ligand bound IGF-II receptors that are internalized per unit of time, as evidenced by a large increase in the photolabeling of intracellular membrane IGF-II receptors when cells are incubated at 37 degrees C with insulin and 4-azidobenzoyl-125I-IGF-II prior to photoactivation ; and 3 ) increases the rate of cellular 125I-IGF-II degradation by a process that is blocked by anti-IGF-II receptor antibody
Lim et al., Exp Cell Res 1985 : Since insulin is required at a concentration well above the physiologic serum level, and must be used at a dose 1000 times higher than IGF-II, we suspected that insulin acts on IGF-II receptors
Corvera et al., Proc Natl Acad Sci U S A 1985 : Insulin action in adipocytes leads to an increase in the steady-state number of cell surface glucose transporters and insulin-like growth factor II (IGF-II) receptors that appear to cycle continuously between the plasma membrane and a low-density membrane fraction
Bassas et al., Endocrinology 1985 : We conclude from these data that IGF receptors develop in chick embryo brain before insulin receptors and probably can mediate effects of IGF and insulin at early stages of embryogenesis
Kadota et al., J Biol Chem 1987 : IGF-II binding was increased by maximally effective doses of vanadate ( 1 mM ), H2O2 ( 1 mM ), and insulin ( 10 ng/ml ) to 172 +/- 10, 138 +/- 12, and 289 +/- 16 % of control, respectively
van Dijk et al., J Endocrinol 1988 : Rat insulin-like growth factor (IGF)-II in the presence of insulin promoted a dose dependent increase in mitogenic activity, with a half-maximal concentration of approximately 1 microgram/l ; IGF-II had no effect in the absence of insulin
Vetter et al., Basic Res Cardiol 1988 : Insulin at a concentration of 6,250 and 12,500 microU/ml increased the contractility by 11 and 18 % ; IGF-I at a concentration of 12 and 25 ng/ml, and IGF-II at a concentration of 25 and 50 ng/ml increased the contractility by 16 and 22 %, and 13 and 18 %, respectively
Rogers et al., Proc Natl Acad Sci U S A 1988 : IGF-II stimulated increases in Ins-P3 did not occur when basolateral membranes were suspended in the absence of free calcium
Dahmer et al., Endocrinology 1988 (Adrenal Gland Neoplasms...) : These data suggest that insulin and IGFs are growth factors for PC12 cells, and that the growth promoting effects of these agents may be mediated by a type I IGF receptor on PC12 cells
Verspohl et al., J Clin Invest 1984 (Carcinoma, Hepatocellular...) : A mouse monoclonal antibody to the human insulin receptor that inhibits insulin binding and blocks insulin action inhibited 75 % of 125I-insulin binding, but inhibited neither 125I-IGF-I nor 125I-IGF-II binding
Mössner et al., J Biol Chem 1984 (Diabetes Mellitus) : We now report that the binding of 125I labeled IGF II to mouse pancreatic acini is maximally increased by 100 nM insulin ( 51 % ) and is maximally reduced by 10 nM cholecystokinin octapeptide ( CCK8 ) ( 34 % ), but is not affected by other regulatory peptides such as somatostatin or glucagon
Tally et al., Biosci Rep 1984 (Leukemia, Erythroblastic, Acute) : Instead insulin , present in high concentrations, enhanced the binding of IGF-II
Posner et al., Can J Biochem 1980 : In contrast ILAs and IGF-1 and IGF-2 inhibited 125I labeled insulin binding to its receptors in a dose dependent fashion
Czech et al., Fed Proc 1983 (Carcinoma, Ehrlich Tumor) : For example, an effect of insulin mediated through its own receptor in intact adipocytes or H-35 hepatoma cells rapidly results in a 5- to 10-fold increase in the affinity of the 250,000-dalton IGF-II receptor for 125I labeled IGF-II
Williams et al., Am J Physiol 1984 (Diabetes Mellitus, Experimental) : By contrast, insulin increases the binding of 125I-IGF-II to its receptor ... IGF in turn inhibits 125I-insulin binding to its receptor but with 250-fold less potency
Potau et al., Biochem Biophys Res Commun 1984 : Cholecystokinin and insulin regulate insulin-like growth factor II binding to pancreatic receptors ; evidence of a role for intracellular calcium ... The binding of 125I labeled insulin-like growth factor II ( 125I-IGF II ) to mouse pancreatic acini was stimulated ( 45 % ) by insulin and inhibited ( 30 % ) by cholecystokinin octapeptide ( CCK8 ) ... Two lines of evidence suggest that this effect of cholecystokinin on basal and insulin stimulated 125I-IGF II binding was mediated via a change in intracellular calcium : ( 1 ) the cholinergic agent carbachol inhibited IGF II binding to its receptors ; ( 2 ) addition of the Ca2+ ionophore A23187 mimicked the effects of CCK8 and carbachol
Wardzala et al., J Biol Chem 1984 : Previous studies have proposed that insulin increases the binding of insulin-like growth factor II (IGF-II) in isolated rat adipose cells at 24 degrees C by increasing receptor affinity ( Ka ) ... Insulin induces a 5-fold increase in cell surface IGF-II receptors without a change in affinity when IGF-II binding is measured in the presence of KCN ... These data suggest that ( a ) the effects of KCN reflect a selective blockade of endocytosis ; ( b ) in the absence of KCN, IGF-II binds to receptors of constant affinity that cycle between the plasma membrane and an intracellular pool resulting in an accumulation of intracellular IGF-II ; ( c ) insulin induces an increase in IGF-II binding by causing a steady state redistribution of receptors from this intracellular pool to the plasma membrane ; and ( d ) this redistribution in the intact cell can only be detected using Scatchard analysis when recycling of the receptors is prevented by KCN
Misbin et al., Endocrinology 1983 : Insulin, IGF 1 and IGF 2 inhibited 125I-insulin degradation by this enzyme ... Insulin, IGF 1 and IGF 2 inhibited 125I-insulin degradation by this enzyme
Takano et al., Endocrinology 1980 (Diabetes Mellitus, Experimental...) : Effect of insulin and nutrition on serum levels of somatomedin A in the rat ... The total caloric intakes in the treated and nontreated diabetic rats were similar, suggesting that the low levels of somatomedin A in diabetic rats may be due to lack of insulin
Knight et al., Proc Natl Acad Sci U S A 1981 (Dwarfism...) : Stimulation of glucose incorporation and amino acid transport by insulin and an insulin-like growth factor in fibroblasts with defective insulin receptors cultured from a patient with leprechaunism
Gallaher et al., Eur J Endocrinol 1994 : Circulating insulin-like growth factor II/mannose-6-phosphate receptor and insulin-like growth factor binding proteins in fetal sheep plasma are regulated by glucose and insulin
Conover et al., Endocrinology 1995 : Effect of glucocorticoid on insulin-like growth factor (IGF) regulation of IGF binding protein expression in fibroblasts
Babajko et al., Growth Regul 1995 (Carcinoma, Hepatocellular...) : Transcriptional regulation of insulin-like growth factor binding protein-1 expression by insulin and cyclic AMP
Ibáñez et al., Fertil Steril 1995 (Hyperandrogenism) : Baseline IGF-I, insulin-like growth factor binding protein-1 ( IGFBP-1 ), IGFBP-3, GH response to the exercise-propranolol test, and insulin responses to a standard oral glucose tolerance test were compared among patients with functional ovarian hyperandrogenism, hyperandrogenic nonfunctional ovarian hyperandrogenism patients, and age matched controls
Confort et al., Endocrinology 1995 (Breast Neoplasms) : Insulin-like growth factors (IGFs) stimulate the release of alpha 1-antichymotrypsin and soluble IGF-II/mannose 6-phosphate receptor from MCF7 breast cancer cells
Morishita et al., Comparative biochemistry and physiology. Comparative physiology 1993 : 5. The binding of [ 125I ] IGF-1 to the 30 kDa protein was inhibited by unlabelled IGF-1 but not by insulin , and saturated with a small amount of the ligand compared to the 150 kDa protein
Nahum et al., Hum Reprod 1995 (Hyperandrogenism...) : These results reveal potent regulatory effects of metabolic hormones on human thecal androgen synthesis, which imply ( i ) ` progonadotrophic ' roles for insulin and IGF-I in regulating normal ovarian androgen production, ( ii ) a role for insulin in the aetiology of hyperandrogenism ( both with and without hyperinsulinism ) in PCOS and ( iii ) paracrine roles for granulosa derived IGF-II and inhibin in regulating ovarian androgen production
Miettinen et al., J Endocrinol 1993 : IGF-1, IGF-II , TGF-alpha or epidermal growth factor-receptor antibody had no significant effect on either insulin or IGF-II mRNA
Seely et al., Endocrinology 1995 : In conclusion, IGF-I stimulated insulin/IGF-I hybrid receptors function like IGF-I receptors, rather than like insulin receptors
Dahms et al., J Biol Chem 1994 : The binding of [ 125I ] IGF-II to the receptors in the presence or absence of excess unlabeled IGF-II, IGF-I, or insulin was determined by incubation with homobifunctional cross linking agents followed by SDS-polyacrylamide gel electrophoresis
Yang et al., Am J Physiol 1994 (Body Weight...) : Dex without IGF-I increased serum insulin concentrations 300 % and glucose concentrations 20 % ; IGF-I plus Dex significantly reduced serum insulin and glucose concentrations to TPN control levels
Kasuya et al., Biochemistry 1993 : 125I-IGF binding to these receptors was inhibited by IGF-I and insulin with IC50s of approximately 2 and approximately 1000 nM, respectively
Ang et al., Brain Res Dev Brain Res 1993 : Insulin , IGF-I or NGF in the absence of astrocytes did not greatly increase the neurite growth
Verspohl et al., Cell Signal 1995 : The data indicate that tyrosine kinase is involved in the inhibitory effects of insulin and IGF on insulin release in INS-1 cells, possibly mediating the negative feedback effect
Giuliano et al., Eur J Biochem 1996 (Retinoblastoma) : IGF-I, IGF-II and insulin induced tyrosine phosphorylation of IGF-IR
Yu et al., Biochim Biophys Acta 1996 (Insulin Resistance) : To further elucidate the mechanisms for short-term regulation of the receptor for insulin-like growth factor II (IGF-II), we investigated effects of insulin , cAMP and phosphatase inhibitors on cell surface 125I-IGF-II binding in rat adipocytes ... Preincubation with the serine/threonine phosphatase inhibitor okadaic acid ( OA, 1 microM ) or the non-hydrolysable cAMP analogue N6-mbcAMP ( 4 mM ) markedly impaired insulin stimulated 125I-IGF-II binding ... In contrast, vanadate did not affect the impairment in maximal insulin stimulated 125I-IGF-II binding produced by either OA or N6-mbcAMP
Hu et al., Endocrinology 1996 : Growth hormone modulates insulin regulation of hepatic insulin-like growth factor binding protein-1 transcription
Vafiadis et al., J Autoimmun 1996 (Diabetes Mellitus, Type 1) : In an effort to define the pathophysiologic mechanism of the IDDM2 effect, we examined the effect , in cis, of VNTR genotype on steady-state mRNA levels of INS in samples of human fetal pancreas, and of IGF2 in leucocytes of diabetic children
Costantino et al., Endocrinology 1996 (Breast Neoplasms) : Interleukin-1 blocks insulin and insulin-like growth factor stimulated growth in MCF-7 human breast cancer cells by inhibiting receptor tyrosine kinase activity
Band et al., J Biol Chem 1997 : Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline ( bpV ( phen ) ) inhibition of insulin-like growth factor binding protein gene expression
Oddy et al., Am J Physiol 1996 : Systemically, IGF-I reduced plasma insulin , phenylalanine, tyrosine, isoleucine, and leucine in all nutrition groups
Zhao et al., Proc Natl Acad Sci U S A 1997 : More specifically, in both isolated pancreatic islets and insulin secreting HIT-T15 cells, IGF-1 inhibits insulin secretion that has been increased by glucose and glucagonlike peptide 1 (GLP-1) ... However, IGF-1 does not inhibit insulin secretion stimulated by nonhydrolyzable cAMP analogs
Hill et al., J Endocrinol 1997 : IGF-II ( 13.3 nM ) did not significantly increase insulin release, while 53 nM IGF-II significantly inhibited release of insulin relative to controls
Zhang et al., Biochem Biophys Res Commun 1998 : We have investigated the effect of IGF-II on glucose induced insulin release in the pancreatic beta-cell ... In addition, IGF-II inhibited Ca ( 2+ ) -induced insulin release from electropermeabilized pancreatic beta-cells ... IGF-II had no effect on K ( + ) -or tolbutamide induced insulin release ... However, IGF-II could suppress K ( + ) -stimulated insulin release when cells were pretreated with the protein phosphatase inhibitor okadaic acid ... The inhibitory effect of IGF-II on insulin release was not associated with significant changes in membrane potential, activity of the voltage gated L-type Ca ( 2+ ) -channel or cytoplasmic free Ca2+ concentration
Cichy et al., J Biol Chem 1998 : Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor binding protein-1 gene expression through a conserved insulin response sequence
Zhang et al., J Endocrinol 1998 (Insulinoma) : Under basal conditions, IGF-I did not induce insulin release or changes in cytosolic free Ca2+ concentration
White et al., Comp Biochem Physiol B Biochem Mol Biol 1998 : Insulin-like growth factors (IGFs) are potent stimulators of cellular growth and their half-life and biological activity are regulated by specific IGF binding proteins ( IGFBPs )