Franceschini et al., Hepatology 2011
:
Insulin ( 100 and 1000 nM ) significantly reduced in a dose dependent fashion IFN induced gene expression of PKR ( P=0.017 and P=0.0017, respectively ), MxA ( P=0.0103 and P=0.00186 ), and 2'-5 ' oligoadenylatesynthetase 1 (OAS-1) ( P=0.002 and P=0.006 )
Chelbi-Alix et al., Exp Cell Res 1994
:
However, whereas both insulin and dsRNA efficiently induced 2'5 ' oligoadenylate synthetase and an antiviral state through interferon synthesis in HT-29 cells, only dsRNA caused these effects in MDBK cells