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INS — PMS2
Text-mined interactions from Literome
Akpan et al., Acta Diabetol Lat 1987
:
This investigation was initiated to characterize the
stimulation of
insulin secretion by
phenazine methosulfate ( PMS ) ... Islets of Langerhans, isolated by the collagenase method from normal rats and rats pre injected with either streptozotocin or 6-aminonicotinamide, were exposed to PMS under various experimental conditions and
insulin secretion in
response to
PMS , glucose and pyridine nucleotides was determined ... After exposure of islets to beta-cytotoxin either in vivo or in vitro, complete reversal of the cytotoxic effect was obtained with
PMS which
induced release of
insulin in both normal and beta-cytotoxin islets pre treated
Akpan et al., Acta Diabetol Lat 1982
(Diabetes Mellitus, Experimental) :
PMS ( 0.5 mM )
increased the level of NADP+ + NADPH content of islets and augmented
insulin secretion