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INS — RAC2

Text-mined interactions from Literome

Dadke et al., J Biol Chem 2003 : Rat fibroblasts lacking PTP1B expression do not activate Src or Rac in response to insulin and can not reorganize actin
Amin et al., Endocrinology 2003 : Further, stable expression of a dominant negative ( N17Rac ) form of Rac into INS-1 cells resulted in a significant reduction in mastoparan stimulated insulin secretion from these cells
JeBailey et al., Diabetes 2007 (Insulin Resistance) : Ceramide- and oxidant induced insulin resistance involve loss of insulin dependent Rac-activation and actin remodeling in muscle cells ... Here, we show that insulin dependent Rac activation and its consequent actin remodeling were abolished upon exposure of L6 myotubes beginning at doses of C2-ceramide or oxidant producing glucose oxidase as low as 12.5 micromol/l and 12.5 mU/ml, respectively
Kohn et al., EMBO J 1995 : Insulin stimulates the kinase activity of RAC-PK , a pleckstrin homology domain containing ser/thr kinase