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PPP2CA — XRCC6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 244 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009

Text-mined interactions from Literome

Wang et al., Neoplasia (New York, N.Y.) 2009 : Specific disruption of PP2A by either expression of SV40 small tumor antigen or depletion of endogenous PP2A/C by RNA interference inhibits Ku DNA binding and DNA-PK activities, which results in suppression of DNA double-strand break ( DSB ) repair and DNA end joining in association with increased genetic instability ( i.e., chromosomal and chromatid breaks ) ... Overexpression of the PP2A catalytic subunit (PP2A/C) enhances Ku and DNA-PK activities with accelerated DSB repair
Li et al., J Biol Chem 2013 : Exposure of cancer cells to rapamycin increased DNA-PK activity, and gene silencing mediated PP2A inhibition attenuated rapamycin induced DNA-PK activity