Gene interactions and pathways from curated databases and text-mining

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EPHB2 — IL17A

Text-mined interactions from Literome

Kinugasa et al., Gastroenterology 2000 (Colonic Neoplasms...) : Inhibition of ERK activation with the MEK inhibitor PD98059 blocked IL-17 as well as basal development of tight junctions in T84 cells
Wuyts et al., J Heart Lung Transplant 2005 : Western blotting clearly demonstrated that p38 MAPK, JNK and p42/p44 ERK were activated by IL-17 in HASMC ... We found that IL-17 induces activation of p38MAPK, JNK and p42/p44ERK in HASMC
Ning et al., Am J Physiol Lung Cell Mol Physiol 2005 (MAP Kinase Signaling System) : CO exposure selectively attenuated IL-17 induced ERK1/ERK2 MAPK activation without significantly affecting either JNK or p38 MAPK activation
Patel et al., J Biol Chem 2007 : IL-17 stimulated p38 MAPK and ERK1/2 activation, and SB203580 and PD98059 blunted IL-17 mediated NF-kappaB and C/EBP activation and CRP transcription
Cortez et al., Am J Physiol Heart Circ Physiol 2007 : IL-17 induced p38 MAPK and ERK1/2 activation, and inhibition by SB-203580 and PD-98059 blunted IL-17 mediated transcription factor activation and MMP-1 expression
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Pretreatment with the phytoalexin resveratrol blocks HG-induced PI3K-, Akt-, and ERK dependent IL-17 expression
Cheung et al., J Immunol 2008 (Inflammation) : Further investigations showed that IL-17A , IL-17F, and IL-23 differentially activated the ERK , p38 MAPK, and NF-kappaB pathways
Hosokawa et al., Cell Physiol Biochem 2009 : EGCG and ECG prevented IL-17A induced phosphorylation of p38 MAPK and ERK in HGFs
van de Veerdonk et al., J Leukoc Biol 2010 : The MAPK Erk , known to mediate transcription of IL-1beta mRNA, was strongly involved in the IL-17A production induced by MTB
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : The IL-17 stimulated ERK 1/2, p38, and JNK MAPK activities and GSPE decreased IL-17 stimulated ERK 1/2, p38, and JNK MAPK activities
Fang et al., J Leukoc Biol 2011 (Mycobacterium Infections) : We also demonstrated that IL-17A activated the phosphorylation of ERK1/2 triggered by BCG
Valente et al., Cell Signal 2012 (Fibrosis...) : IL-17A mediated p38 MAPK and ERK1/2 activation is inhibited by MKP-1 overexpression, but prolonged by MKP-1 knockdown
Zhang et al., World J Gastroenterol 2012 (Inflammation...) : IL-17A induced rapid phosphorylation of p38 MAPK and ERK1/2 after 5 min exposure, and showed the strongest levels of phosphorylation of p38 MAPK and ERK1/2 at 15 min in IL-17A treated HSCs. IL-6 mRNA expression induced by IL-17A ( 100 ng/mL ) for 3 h exposure was inhibited by preincubation with specific inhibitors of p38 MAPK ( SB-203580 ) and ERK1/2 ( PD-98059 ) compared to groups without inhibitors preincubation ( 1.67 ± 0.24, 2.01 ± 0.10 vs 4.08 ± 0.59, P < 0.01 )
Richter et al., Arthritis Rheum 2012 (Arthritis, Experimental...) : In isolated and cultured rat DRG neurons, IL-17A caused rapid phosphorylation of protein kinase B and ERK , and it rapidly enhanced excitability
Meephansan et al., J Dermatol Sci 2013 : IL-17A caused phosphorylation of EGFR, ERK , p38, and STAT1 ... IL-17A induced IL-33 in NHEKs through EGFR, ERK , p38, and JAK/STAT1 pathways, which were necessary for the induction of IL-33