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EPHB2 — MMP28

Text-mined interactions from Literome

Sylvester et al., Cell Signal 2004 : ERK pathway inhibitors, PD98059 and U0126, down-regulated IL-17 induced MMP and ADAM-TS4 gene expression
Shah et al., Mol Endocrinol 2004 : Agonist mediated MMP activation in C9 cells led to shedding of heparin binding EGF (HB-EGF) and stimulation of ERK1/2 phosphorylation
Purdom et al., J Pharmacol Exp Ther 2005 : In HFs, MMP inhibitors GM6001 [ N- [ ( 2R ) -2- ( hydroxamidocarbonylmethyl ) -4-methylpentanoyl ] -l-tryptophan methylamide ] and BB2516 [ [ 2S- [ N4 ( R ( * ) ) ,2R ( * ) ,3S ( * ) ] ] -N4- [ 2,2-dimethyl-1- [ ( methylamino ) carbonyl ] propyl ] -N1,2-dihydroxy-3- ( 2-methylpropyl ) butanediamide, marimastat ] inhibited JNKs and ERK1/2 activation without affecting p38 activation by H ( 2 ) O ( 2 ) inhibitors
Spallarossa et al., Cardiovasc Res 2006 (MAP Kinase Signaling System) : To investigate the signaling pathways leading to doxorubicin induced MMP activation, we also examined the phosphorylation of three members of the MAPK family ( ERK1/2, p38, and JNK ), the effects of selective inhibitors of ERK1/2 , p38, and JNK on MMP transcription and activity, the transcription of the NAD ( P ) H oxidase subunit Nox1, and the effects of the NAD ( P ) H oxidase inhibitor DPI on MMP activation
Shah et al., J Neurochem 2006 : Phe induced phosphorylation of the EGF-R, and subsequently of Shc and ERK1/2 , was attenuated by inhibition of MMP or HB-EGF with the selective inhibitor, CRM197, or by a neutralizing antibody ... In contrast, phosphorylation of the EGF-R, Shc and ERK1/2 by EGF and HB-EGF was independent of PKC and MMP activity
Yang et al., J Pharmacol Exp Ther 2006 (Stomach Ulcer) : rCRAMP also increased EGFR and ERK1/2 phosphorylation via an MMP dependent mechanism
Aitken et al., Am J Pathol 2006 (Mechanotransduction, Cellular) : Similarly, stretching BSMCs in vitro induced increases in ERK1/2 activation and ERK1/2 dependent proliferation under discrete mechanical conditions, and distension conditioned medium itself induced MMP dependent ERK1/2 activation in BSMCs. Overall, stretch induced proliferation and ERK1/2 signaling in bladder tissue and BSMCs likely depend on secreted MMP activity
Meriane et al., Stem Cells 2006 (MAP Kinase Signaling System) : Moreover, MMP- and ROCK dependent molecular events are implicated in the regulation of the S1P induced activation of ERK
Lin et al., J Biol Chem 2008 : This study provides the first evidence that MMP mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses
Xie et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colonic Neoplasms) : ACh induced MMP1, MMP7 , and MMP10 gene transcription was attenuated by atropine, anti-EGFR antibody, and chemical inhibitors of EGFR and ERK activation
Pan et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2010 : To investigate the effect of ERK signaling pathway and MMP-9 on migration of hPDLC, the cells were incubated with PD98059, a specific extracellular signal regulated kinase ( ERK ) kinase inhibitor, or doxycycline, a MMP inhibitor
Li et al., Phytomedicine 2010 (Hyperplasia) : However, HG-down regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Ta et al., Atherosclerosis 2010 : Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and ERK dependent MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Lee et al., J Biol Chem 2013 (Neoplasm Invasiveness...) : Blockade of p21 ( WAF1 ) function by siRNA reversed migration, invasion, activation of ERK signaling, MMP-9 expression, and activation of NF-?B in IL-20 treated cells