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EPHB2 — WDR61
Text-mined interactions from Literome
Ahamed et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
In contrast, these inhibitors almost completely blocked both
PAF induced
ERK phosphorylation and LTC ( 4 ) generation in PAFR cells ... However, in mPAFR cells pertussis toxin only partially inhibited
PAF induced
ERK phosphorylation ... A Ca ( 2+ ) /calmodulin inhibitor had no effect on
PAF induced
ERK phosphorylation in PAFR cells but completely blocked the response in mPAFR cells
Wang et al., Oncogene 2003
(Carcinoma...) :
PAF activated three prominent mitogen activated protein kinase modules (
ERK , p38MAPK and Jun N-terminal kinases ) in these cells, inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA )
Khreiss et al., Cell Signal 2004
(Inflammation) :
These results indicate that
PAF induced activation of
ERK contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis, thereby amplifying the inflammatory response
Zhou et al., Am J Physiol Heart Circ Physiol 2007
:
PAF also
stimulated activation of both
ERK and p38 but not c-Jun NH ( 2 ) terminal kinase ( JNK ) mitogen activated protein ( MAP ) kinase pathways
Dorado et al., Nephrol Dial Transplant 2008
:
In cultured human mesangial cells,
Erk5 was
activated by foetal calf serum ( FCS ), high glucose, endothelin-1,
platelet activating factor (PAF) , epidermal growth factor (EGF) and transforming growth factor beta-1 ( TGF-beta1 )
Kim et al., Eur J Cancer 2012
(Lung Neoplasms...) :
ERK , JNK, and p38 MAPKs were
activated rapidly by
PAF in the lungs, and the PAF induced metastasis of B16F10 was inhibited in a dose dependent manner by pretreatment with either U0126 ( ERK inhibitor ), SP600125 ( JNK inhibitor ), or SB202190 ( p38 inhibitor )
Hirabayashi et al., Biochem Biophys Res Commun 1998
:
Stimulation of
platelet activating factor (PAF) receptor
induces activation of extracellular signal regulated kinase (
ERK ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells
Zhang et al., J Biol Chem 1999
:
The
PAF induced p38 and
ERK pathways appeared to be preferentially regulated by RGS16 and RGS1, respectively