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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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BIRC5 — CUL3

Pathways - manually collected, often from reviews:

  • NCI Pathway Database Aurora B signaling: Aurora B/HC8 Proteasome complex (AURKB-PSMA3) → Chromosomal passenger complex/Cul3 protein complex complex (AURKB-INCENP-BIRC5-CDCA8-CUL3-KLHL13-KLHL9) (modification, collaborate)
    Shu et al., Mol Cell Biochem 2003
    Evidence: assay, physical interaction
  • NCI Pathway Database Aurora B signaling: Chromosomal passenger complex/Cul3 protein complex complex (AURKB-INCENP-BIRC5-CDCA8-CUL3-KLHL13-KLHL9) → HC8 Proteasome subunit alpha (PSMA3) (modification, collaborate)
    Shu et al., Mol Cell Biochem 2003
    Evidence: assay, physical interaction
  • NCI Pathway Database Aurora B signaling: Cul3 protein complex complex (CUL3-KLHL9-KLHL13) → Chromosomal passenger complex/Cul3 protein complex complex (AURKB-INCENP-BIRC5-CDCA8-CUL3-KLHL13-KLHL9) (modification, collaborate)
    Sumara et al., Dev Cell 2007
    Evidence: mutant phenotype, assay
  • NCI Pathway Database Aurora B signaling: Cul3 protein complex complex (CUL3-KLHL9-KLHL13) → Chromosomal passenger complex complex (AURKB-INCENP-BIRC5-CDCA8) (modification, collaborate)
    Sumara et al., Dev Cell 2007
    Evidence: mutant phenotype, assay
  • NCI Pathway Database Aurora B signaling: Chromosomal passenger complex/Cul3 protein complex complex (AURKB-INCENP-BIRC5-CDCA8-CUL3-KLHL13-KLHL9) → Chromosomal passenger complex complex (AURKB-INCENP-BIRC5-CDCA8) (modification, collaborate)
    Sumara et al., Dev Cell 2007
    Evidence: mutant phenotype, assay