Verrecchia et al., J Biol Chem 2003
:
We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not inhibit the formation of SMAD-DNA complexes and the resulting SMAD-driven transcription in response to TGF-beta
Kang et al., Proc Natl Acad Sci U S A 2005
(Bone Neoplasms...) :
Activator protein-1 is a key participant in Smad dependent transcriptional activation of IL-11 and its overexpression in bone-metastatic cells
Kido et al., PloS one 2010
:
The present study was undertaken to clarify whether mechanical stress affects BMP-Smad signaling, and if so, to elucidate the role of Smad signaling in mechanical stress induced enhancement of IL-11 gene transcription
Gupta et al., Cancer Biol Ther 2011
(Bone Neoplasms...) :
TGFß dependent induction of interleukin-11 and interleukin-8 involves SMAD and p38 MAPK pathways in breast tumor models with varied bone metastases potential