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IL13 — MAPK9
Text-mined interactions from Literome
McDermott et al., J Biol Chem 2002
:
Ras participates in the
activation of p38
MAPK by
interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
Harlin et al., J Immunol 2002
(MAP Kinase Signaling System) :
Together, these results suggest that TCR independent CD30 mediated production of
IL-13 is
triggered by association of CD30 with TRAF family members and subsequent activation of p38
MAPK
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Jee et al., J Invest Dermatol 2002
(Carcinoma, Basal Cell...) :
Next,
interleukin-6 stimulation elicited extracellular signal regulated kinase activation in basal cell carcinoma cells, and the
mitogen activated protein kinase inhibitor, PD98059, could
affect this response without affecting the interleukin-6-medi ated Mcl-1 upregulation
Xu et al., Mol Cell Biol 2003
:
Interleukin-13 induction of 15-lipoxygenase gene expression
requires p38
mitogen activated protein kinase mediated serine 727 phosphorylation of Stat1 and Stat3
Iwashita et al., Immunol Cell Biol 2003
(Colonic Neoplasms) :
Interleukin-4 and
IL-13 activated phosphorylation of
mitogen activated protein kinase in LS174T cells
Xu et al., J Biol Chem 2004
:
Furthermore, our data demonstrate that
IL-13 mediated activation of PKCdelta and p38
MAPK are independent pathways, because inhibition of one kinase activity had no effect on the other, suggesting that the two pathways act in parallel to regulate the downstream targets necessary for 15-LO expression
Mason et al., Infect Immun 2004
:
TRAF6 dependent
mitogen activated protein kinase activation differentially
regulates the production of
interleukin-12 by macrophages in response to Toxoplasma gondii
Fujisawa et al., Respirology 2008
(Metaplasia) :
Cycloheximide also diminished activation of p38
MAPK and
induction of MUC5AC mRNA expression by
IL-13
Hamdi et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
As a functional
consequence of this PLD2 dependent
MAPK activation,
interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2
Park et al., J Biol Chem 2009
:
Furthermore, expression and production of
IL-13 increased by Der f 2 were also
blocked by inhibition of PLCgamma, PKCalpha, or p38
MAPK , indicating that IL-13 expression and production are related to a PLCgamma/PKCalpha/p38 MAPK pathway
Kono et al., Pulm Pharmacol Ther 2010
(Asthma) :
Furthermore, DMS inhibited
IL-13 induced ERK1/2 phosphorylation but neither p38
MAPK nor STAT6 phosphorylation
Munitz et al., Gastroenterology 2010
(Colitis...) :
In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6,
interleukin-1beta , and tumor necrosis factor alpha ) and
activation of
MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Glossop et al., J Tissue Eng Regen Med 2010
:
In a previous gene expression study, we reported a potentially important
role for mitogen activated protein kinase kinase kinase 8 ( MAP3K8 ) and
interleukin-1ß ( IL-1B ) in
MAPK signalling in MSCs exposed to fluid shear stress
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced
activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Bhattacharjee et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Our data show that Src kinase activity regulates
IL-13 induced p38
MAPK tyrosine phosphorylation via the upstream kinases MKK3 or MKK6 ... Our findings also reveal that the
IL-13 receptor associated tyrosine kinase Jak2 is
required for the activation of both Src kinase as well as p38
MAPK
Dauphinee et al., Am J Physiol Heart Circ Physiol 2011
:
We find that Ga ( i/o ) -mediated activation of the
MAPK is
independent of the canonical MyD88,
interleukin-1 receptor associated kinase, and tumor necrosis factor receptor associated factor 6 signaling cascade in LPS stimulated cells
Zhou et al., J Immunol 2012
(Asthma...) :
MAPK regulation of
IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-ß1 and IL-13 in human airway fibroblasts
van den Elsen et al., Br J Nutr 2013
(Hypersensitivity...) :
Inhibition of
MAPK signalling, but not NF-?B, downstream of ROS
reduced IL-13 secretion by activated HMC-1
Tormos et al., Hepatology 2013
(Chronic Disease...) :
p38a mitogen activated protein kinases (
MAPK ) may be essential in the up-regulation of proinflammatory cytokines and can be
activated by transforming growth factor ß, tumor necrosis factor-a,
interleukin-1ß , and oxidative stress