Zimmermann et al., Am J Respir Cell Mol Biol 2005
(Asthma...) :
Transgenic overexpression of interleukin (IL)-13 in the lungs resulted in a marked increase of SPRR2 expression, and allergen induced SPRR2 expression was significantly decreased in IL-13-deficient mice
Finkelman et al., J Immunol 2005
(Bronchial Hyperreactivity) :
Only the collagen alpha2 type VI (Ca2T6) gene and three small proline-rich protein ( SPRR ) genes were reproducibly induced > 4-fold more by IL-13 than by IL-4