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IL13 — TGFB1

Text-mined interactions from Literome

Lee et al., J Exp Med 2001 (Pulmonary Fibrosis) : We hypothesized that the fibrogenic effects of IL-13 are mediated by transforming growth factor ( TGF ) -beta ... IL-13 selectively stimulated TGF-beta(1) production in transgenic animals and macrophages were the major site of TGF-beta(1) production and deposition in these tissues ... IL-13 also activated TGF-beta(1) in vivo
Bry et al., Am J Obstet Gynecol 1992 (Obstetric Labor, Premature) : Human amnion cells in monolayer culture were treated with interleukin-1 , tumor necrosis factor, or vehicle in the presence or absence of transforming growth factor-beta
Kumar et al., Clin Exp Allergy 2004 (Asthma...) : Production of epithelial cell derived TGF-beta 1 appeared to be regulated by IL-13, while both IL-13 and CD4 ( + ) T cells regulated accumulation of TGF-beta 1
Zhou et al., Am J Physiol Cell Physiol 2005 : These results suggest that IL-13 augments TGF-beta1 induced profibrotic responses at both the mRNA and protein levels
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Finotto et al., Int Immunol 2005 (Asthma) : IL-13 blockade also led to reduced eosinophilia and decreased vimentin, transforming growth factor beta ( TGF-beta ) and alpha smooth muscle actin ( alphaSMA ) levels
Roberts et al., Mol Hum Reprod 2005 : We also showed that tumour necrosis factor-alpha ( TNF-alpha ; 10 and 25 ng/ml ) and transforming growth factor-beta ( TGF-beta; 1 and 5 ng/ml ), cytokines with inflammatory and immune regulatory functions in a cell- and dose dependent manner regulate the expression of IL-13 and IL-15 ( P < 0.05 )
Fichtner-Feigl et al., Nat Med 2006 (Colitis...) : IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis ... In studies of the mechanisms underlying such induction, we found that IL-13 induces transforming growth factor (TGF)-beta(1) in macrophages through a two-stage process involving, first, the induction of a receptor formerly considered to function only as a decoy receptor, IL-13Ralpha(2)
Shim et al., J Immunol 2006 (Chronic Disease...) : Lastly, mechanistic insights are provided by demonstrating that IL-13 induced 5-LO activation is required for optimal stimulation and activation of TGF-beta(1) and the inhibition of matrix metalloproteinase-12
Ito et al., Int Arch Allergy Immunol 2008 (Bronchial Hyperreactivity) : IL-13 levels increased up to 14 days, peaking at 48 h. Increases in BAL fluid transforming growth factor-beta(1) and platelet derived growth factor were observed at 12 h, and remained elevated at 14 days
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Shimamura et al., Clin Cancer Res 2010 (Adenocarcinoma...) : IL-13 induced transforming growth factor-beta1 promoter activity in IL-13Ralpha2 positive tumor cells and in cells engineered to express IL-13Ralpha2 but not in IL-13Ralpha2 negative or RNA interference knockdown cells ... IL-13 causes transforming growth factor-beta activation via AP-1 pathway, which may cause tumor induced immunosuppression in the host
Kumar et al., J Cell Physiol 1996 : Induction of interleukin-1 and interleukin-8 mRNAs and proteins by TGF beta 1 in rat lung alveolar epithelial cells
Marth et al., Eur J Immunol 1997 : Regulation of transforming growth factor-beta production by interleukin-12
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra