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Kang et al., Biochem Pharmacol 2002 : Berberine induced IL-12 p40 production and activation of p38 mitogen activated protein kinase ( MAPK ) in dose dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha ( 2 ) -adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine
Jana et al., J Neurochem 2003 : In addition, we show that p40 induced the activation of both extracellular signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK )
Jana et al., Glia 2009 (MAP Kinase Signaling System) : IL-12 p40 ( 2 ) alone induced the activation of both extracellular signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK )