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CAV2 — MAPK7
Text-mined interactions from Literome
Minelli et al., Peptides 2006
:
It greatly
enhances the phosphorylation of hsp27, alpha-B-crystallin, Cdc2, and p-38
MAPK , whereas it decreases the phosphorylation of MEK1,
Cav 2 , GSK3a, PKB/Akt, PKCdelta, PKCgamma, and Erk2
Wang et al., Am J Respir Cell Mol Biol 2006
(Inflammation) :
p38
mitogen activated protein kinase ( MAPK ) phosphorylation was
increased by overexpressing
caveolin-1 in RAW264.7 cells, whereas c-Jun N-terminal kinase, extracellular signal regulated kinase MAPK, and Akt phosphorylation were inhibited
Chen et al., Oncogene 2009
(Neoplasm Invasiveness...) :
Further study revealed that the upregulation of
caveolin-1 and inhibition of tumor cell invasion were
mediated by reactive oxygen species induced p38
MAPK activation
Lv et al., Inflamm Res 2010
(Inflammation) :
Over-expression of
caveolin-1 not only increased the production of pro-inflammatory cytokine TNF-alpha and IL-6, but also
enhanced the expression of the cPLA2, p38
MAPK , and NF-kappaB
Jagielska et al., Arterioscler Thromb Vasc Biol 2012
(Disease Models, Animal...) :
Accordingly, cellular cholesterol depletion ( cyclodextrin ) and silencing of
caveolin-1 ( small interfering RNA )
inhibited IL-1ß induced activation of
p38-MAPK and MK2, as well as IL-1ß induced tube formation and migration