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ESR2 — MAPK7
Text-mined interactions from Literome
Improta-Brears et al., Proc Natl Acad Sci U S A 1999
(Breast Neoplasms) :
In this study, we have used a pharmacological approach to dissect this novel pathway in MCF-7 breast cancer cells and have determined that in the
presence of endogenous
estrogen receptor , activation of
MAPK by E2 is preceded by a rapid increase in cytosolic calcium
Ostrovsky et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Specific
activation of
MAPK by expression of an active
Raf1-estrogen receptor chimera protein reduced significantly the number of myoblasts undergoing programmed cell death in the differentiation medium
Tang et al., Endocrinology 2004
(Breast Neoplasms...) :
Thyroid hormone causes
mitogen activated protein kinase dependent phosphorylation of the nuclear
estrogen receptor
Simoncini et al., Steroids 2004
:
For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the
estrogen receptor dependent activation of
MAPK and PI3K, leading to relevant pathophysiological consequences, in vitro and in vivo
Acconcia et al., J Cell Physiol 2005
:
On the other hand, the
E2-ER beta complex
induced the rapid and persistent phosphorylation of
p38/MAPK which, in turn, was involved in caspase-3 activation and cleavage of poly ( ADP-ribose ) polymerase, driving cells into the apoptotic cycle
Yen et al., Mol Pharmacol 2005
:
Taken together, such results provide evidence that diosgenin up-regulates VEGF-A and promotes angiogenesis in preosteoblast-like cells by a hypoxia-inducible factor-1alpha dependent mechanism involving the
activation of src kinase, p38
MAPK , and Akt signaling pathways via
estrogen receptor
Majidi et al., Cancer Res 2007
(Adenocarcinoma...) :
ERbeta enhanced NNK induced cyclic AMP accumulation as well as Galphai mediated
mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) 1/2 activation
Wang et al., Biochim Biophys Acta 2008
(Breast Neoplasms) :
The
estrogen receptor interacting protein HPIP
increases estrogen-responsive gene expression through activation of
MAPK and AKT ... Here, we report that hematopoietic PBX interacting protein ( HPIP ) interacts both with ERalpha and with
ERbeta , and
increases ERalpha target gene expression through activation of
MAPK and AKT and enhanced ERalpha phosphorylation
Hershberger et al., J Steroid Biochem Mol Biol 2009
(Carcinoma, Non-Small-Cell Lung...) :
Estrogen receptor beta (ERbeta) subtype-specific ligands
increase transcription, p44/p42
mitogen activated protein kinase ( MAPK ) activation and growth in human non-small cell lung cancer cells
Yamnik et al., FEBS Lett 2010
(Breast Neoplasms) :
mTOR/S6K1 and
MAPK/RSK signaling pathways coordinately
regulate estrogen receptor alpha serine 167 phosphorylation
Mendoza et al., J Endocrinol 2011
:
The reduction in the p38
MAPK activity
caused a significant increase in the expressions of
estrogen receptor-a ( ERa ) and the progesterone receptor, but eliminated the expression of ERß
Kato et al., Science 1995
:
Activation of the
estrogen receptor through phosphorylation by
mitogen activated protein kinase
Joel et al., J Biol Chem 1998
:
Estradiol induced phosphorylation of serine 118 in the
estrogen receptor is
independent of p42/p44
mitogen activated protein kinase