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MLST8 — RAD18

Text-mined interactions from Literome

Meikle et al., J Neurosci 2008 (Disease Models, Animal...) : We have tested rapamycin and RAD001 [ 40-O- ( 2-hydroxyethyl ) -rapamycin ], both mammalian target of rapamycin mTORC1 inhibitors , as potential therapeutic agents in this model
Breuleux et al., Mol Cancer Ther 2009 (Neoplasms) : RAD001 ( everolimus ), an mTORC1 ( mTOR/raptor ) inhibitor , has broad antitumor activity in preclinical models and cancer patients
Fujishita et al., Cell cycle (Georgetown, Tex.) 2009 (Adenoma...) : We have recently found that the mTORC1 pathway is activated in intestinal adenomas of Apc mutant mice, accompanied by an elevated level of mTOR protein, and that treatment with RAD001 , an mTORC1 inhibitor , suppresses the growth of these polyps
Park et al., Leukemia 2013 (Leukemia, Myeloid, Acute...) : We conducted a phase Ib trial combining RAD001 ( everolimus ), an allosteric inhibitor of mTORC1 , and conventional chemotherapy, in AML patients under 65 years of age at first relapse ( clinical trial NCT 01074086 )