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MLST8 — RB1CC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1)
→
ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Jung et al., Mol Biol Cell 2009
:
ULK-Atg13-FIP200 complexes
mediate mTOR signaling to the autophagy machinery ... These findings demonstrate that the
ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in
response to
mTOR signaling
Ikeda et al., J Pharmacol Sci 2013
(Adrenal Gland Neoplasms...) :
Indeed, direct
mTORC1 inhibition
initiates ULK1/2 autophosphorylation and subsequent Atg13 and
FIP200 phosphorylation, inducing autophagy