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PGF — PPARG

Text-mined interactions from Literome

Liu et al., J Cell Biochem 2007 : Furthermore, we demonstrate that the inhibitory effects of PGF2alpha on both the expression of PPARgamma and C/EBPalpha and subsequent adipogenesis can be attenuated by treatment of preadipocytes with the histone deacetylase (HDAC) inhibitor trichostatin A. Taken together, these results indicate that PGF2alpha inhibits adipocyte differentiation via a G alpha q-Ca2+-calcineurin dependent signaling pathway that acts to block expression of PPARgamma and C/EBPalpha by a mechanism that appears to involves an HDAC-sensitive step
Liu et al., J Cell Biochem 2008 : Significantly, we demonstrate that the shRNA mediated knockdown of endogenous HIF-1alpha expression attenuates the PGF2alpha induced expression of DEC1, overcomes the inhibitory effects of PGF2alpha on the expression of proadipogenic transcription factors C/EBPalpha and PPARgamma and partially rescues the PGF2alpha induced inhibition of adipogenesis