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RASA1 — SOCS3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: RasGAP/Dok-R complex (RASA1-DOK2) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, inhibits)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → None (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → None (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: RasGAP (RASA1) → SOCS3 (SOCS3) (modification, collaborate) Cacalano et al., Nat Cell Biol 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: RasGAP (RASA1) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, collaborate)
  Cacalano et al., Nat Cell Biol 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SOCS3 (SOCS3) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, collaborate)
  Cacalano et al., Nat Cell Biol 2001
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOCS3 — RASA1 (direct interaction, pull down) Cacalano et al., Nat Cell Biol 2001
• IRef Biogrid Interaction: SOCS3 — RASA1 (physical association, affinity chromatography technology) Cacalano et al., Nat Cell Biol 2001
• IRef Hprd Interaction: SOCS3 — RASA1 (in vivo) Cacalano et al., Nat Cell Biol 2001
• IRef Hprd Interaction: SOCS3 — RASA1 (in vitro) Cacalano et al., Nat Cell Biol 2001
• IRef Intact Interaction: SOCS3 — RASA1 (association, pull down) Cacalano et al., Nat Cell Biol 2001
• IRef Intact Interaction: SOCS3 — RASA1 (association, coimmunoprecipitation) Cacalano et al., Nat Cell Biol 2001
• IRef Ophid Interaction: SOCS3 — RASA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SOCS3 — RASA1 (aggregation, confirmational text mining) Cacalano et al., Nat Cell Biol 2001