UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RasGAP/Dok-R complex (RASA1-DOK2) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database BCR signaling pathway: RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) → SHC/Grb2/SOS1 complex (SOS1-GRB2-SHC1) (modification, inhibits)
Yamanashi et al., Genes Dev 2000, Teixeira et al., Blood 2003, Kumar et al., Biochem J 1995, Hashimoto et al., J Exp Med 1998
WikiPathways EPO Receptor Signaling: Complex of GRB2-RAF1-SOS1-IRS2-JAK2-IRS1-RASA1 → MAP2K1 (activation)