Herbert et al., Nat Cell Biol 2003
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Disjunction of pairs of homologous chromosomes during the first meiotic division ( MI ) requires anaphase promoting complex (APC) mediated activation of separase in budding yeast and Caenorhabditis elegans, but not Xenopus laevis
Yu et al., Cell cycle (Georgetown, Tex.) 2005
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In response to a single straying chromatid within a cell, a surveillance mechanism called the spindle checkpoint blocks the ubiquitin ligase activity of the anaphase promoting complex or cyclosome ( APC/C ), stabilizes securin ( an APC/C substrate and an inhibitor of separase ), and delays the activation of separase Kudo et al., Cell 2006
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Since activation of separase by the anaphase promoting complex (APC/C) is supposedly not required for meiosis I in Xenopus oocytes, it has been suggested that animal cells might resolve chiasmata by a separase independent mechanism related to the so-called `` prophase pathway '' that removes cohesin from chromosome arms during mitosis