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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to BDNF
BDNF — ZNF274
Pathways - manually collected, often from reviews:
NCI Pathway Database p75(NTR)-mediated signaling :
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGFR-BDNF-SORT1-TRAF6)
→
NRIF (ZNF274)
(modification, collaborate)
Gentry et al., J Biol Chem 2004 , Geetha et al., EMBO J 2005
mutant phenotype, assay, other species
NCI Pathway Database p75(NTR)-mediated signaling :
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGFR-BDNF-SORT1-TRAF6)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Gentry et al., J Biol Chem 2004 , Geetha et al., EMBO J 2005
mutant phenotype, assay, other species
NCI Pathway Database p75(NTR)-mediated signaling :
NRIF (ZNF274)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Gentry et al., J Biol Chem 2004 , Geetha et al., EMBO J 2005
mutant phenotype, assay, other species
NCI Pathway Database p75(NTR)-mediated signaling :
JNK family (MAPK8/MAPK9/MAPK10)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Khursigara et al., J Neurosci 2001 , Yeiser et al., J Neurosci 2004 , Linggi et al., J Biol Chem 2005
mutant phenotype, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling :
proBDNF (dimer)/p75 ECD complex (BDNF)
→
p75 CTF/Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274)
(modification, collaborate)
Weskamp et al., J Biol Chem 2004
mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling :
proBDNF (dimer)/p75 ECD complex (BDNF)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Weskamp et al., J Biol Chem 2004
mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling :
p75 CTF/Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Weskamp et al., J Biol Chem 2004
mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling :
TACE (ADAM17)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, activates)
Weskamp et al., J Biol Chem 2004
mutant phenotype, other species