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CASP5 — SMPD2

Text-mined interactions from Literome

Takeda et al., J Biol Chem 1999 : Activation of magnesium dependent neutral sphingomyelinase via caspase-3 ... Moreover, recombinant purified caspase-3 increased magnesium dependent N-SMase in a cell-free system
Fernández-Ayala et al., Antioxid Redox Signal 2000 (Leukemia) : Serum withdrawal induced an early increase of neutral-sphingomyelinase activity, release of ceramide, and activation of caspase-3 in both cell lines, but this effect was more pronounced in CEM cells
Suzuki et al., Int J Oncol 2003 : The enhancement of Fas induced apoptosis by pre-treatment with neuraminidase was inhibited by z-VAD-fmk, a broad caspase inhibitor, and Ac-LEHD-CHO, an inhibitor of caspase-9, but not by Ac-IETD-CHO an inhibitor of caspase-8 or 6, imipramine, an inhibitor of acidic sphingomyelinase, glutathione, an inhibitor of neutral sphingomyelinase and Fumonisin B1, an inhibitor of ceramide synthase
Testai et al., J Neurosci Res 2004 (Oligodendroglioma) : We conclude that caspase 8 activates NSMase in rafts in oligodendrocytes and that the downstream apoptotic signal is via caspase 3
Watanabe et al., Cancer Res 2004 : A caspase-3 inhibitor, acetyl-Asp-Glu-Val-Asp-chloromethyl ketone, blocked not only Fas induced increases of apoptosis and ceramide content but also Fas induced activation of nSMase and inhibition of SM synthase in the nuclear fraction
Neumeyer et al., Exp Cell Res 2006 : This activity of caspase-3 is probably due to activation of neutral sphingomyelinase (N-SMase)