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CCR5 — IL2

Text-mined interactions from Literome

Vassiliadou et al., J Immunol 1999 (HIV Infections) : Progesterone treatment had no effect on constitutive expression of CCR5 and CXCR4 by nonactivated T cells and macrophages, but significantly inhibited IL-2 induced up-regulation of CCR5 and CXCR4 on activated T cells ( p < 0.05 )
Wang et al., J Immunol 1999 : IL-12, but not IL-4, IL-10, or IL-13, now has been shown to down-modulate the surface expression of CCR5 induced by IL-2 on both CD4+ and CD8+ T lymphocytes
Biasin et al., J Infect Dis 2000 : However, interleukin (IL)-6 , IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Pedroza-Martins et al., J Virol 2002 (HIV Infections) : IL-2 and IL-4 together increased expression of CXCR4 and CCR5 in this population, whereas IL-4 and IL-7 increased CXCR4 but not CCR5 expression
Zaunders et al., J Infect Dis 2003 (HIV Infections) : Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection : regulation by interleukin (IL)-2 , IL-15, and Bcl-2
Choudhary et al., J Virol 2005 (HIV Infections) : This finding was likely due to IL-2 induced CCR5 expression on CD4+ thymocytes in FTOC
Zhang et al., Arthritis Rheum 2005 (Arthritis, Rheumatoid) : In contrast, interleukin-12 stimulation induced the up-regulation of CCR5 and a shift in the in vivo homing pattern away from the lymph nodes toward the inflamed synovium
Camargo et al., J Immunol 2009 : Conversely, overexpression of CCR5 in human T cells results in enhanced IL-2 production ... CCR5 surface levels correlate positively with IL-2 protein and mRNA abundance, suggesting that CCR5 affects IL-2 gene regulation
Larruskain et al., Comp Immunol Microbiol Infect Dis 2013 : Sheep with lung lesions showed differential expression in five target genes : CCR5 , TLR7, and TLR8 were up regulated and IL2 and TNFa down regulated
Moriuchi et al., J Immunol 1997 : CCR5 promoter activity was also induced by IL-2 or anti-CD3 Ab, while stimulation with anti-CD28 Ab markedly reduced CD3 mediated up-regulation of the CCR5 promoter