Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PTPN11

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Mañes et al., Mol Cell Biol 1999 (Neoplasm Invasiveness) : Although SHP-2 regulates mitogen activated protein kinase activity, the mitogen activated protein kinase kinase inhibitor PD-98059 has only a marginal effect on MCF-7 cell migration
Oh et al., Mol Cell Biol 1999 : Overexpression of SHPS-1 in 293 cells potentiated integrin induced mitogen activated protein kinase ( MAPK ) activation, and potentiation required functional SHP-2
O'Reilly et al., Mol Cell Biol 2000 : Previously, using a dominant negative mutant approach, we showed that the protein-tyrosine phosphatase SHP-2 is necessary for FGF induced MAPK activation, mesoderm induction, and elongation of animal caps
Inagaki et al., Oncogene 2000 : SHP-2 , a SRC homology 2 domain containing protein tyrosine phosphatase, mediates activation of Ras and mitogen activated protein kinase by various mitogens and cell adhesion
Cunnick et al., J Biol Chem 2001 : Thus, physical association of activated SHP2 with Gab1 is necessary and sufficient to mediate the ERK mitogen activated protein kinase activation
Kontaridis et al., J Cell Sci 2001 : Inhibition of p38 MAPK by SB203580 in differentiating C2C12 myoblasts blocks MyoD expression, SHPS-1 tyrosyl phosphorylation and the association of SHPS-1 with SHP-2
Cai et al., J Cell Biol 2002 (MAP Kinase Signaling System) : Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation
Ruhul Amin et al., Oncogene 2002 : Taken together, our results strongly suggest that activation of Erk 1/2 and Akt by proinflammatory cytokines requires tyrosine phosphorylation of SHPS-1 and subsequent association of SHPS-1 with SHP-2
Lundin Brockdorff et al., Cytokine 2002 (MAP Kinase Signaling System...) : SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells ... The cells transfected with inactive SHP2 showed reduced MAPK activation upon IL-2 stimulation, suggesting that SHP2 upregulates IL-2 induced MAPK activation in T cells ... In conclusion, we show for the first time that SHP2 positively regulates IL-2 induced MAPK activation in malignant T cells
Zhan et al., Cancer Res 2004 (Brain Neoplasms...) : SHP-2 dependent mitogen activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival
Easton et al., J Neurochem 2006 (Neuroblastoma) : Shp2 is required for complete MAPK activation by BDNF, as expression of a dominant negative Shp2 in cells attenuates BDNF induced activation of MAPK
Chen et al., Mol Pharmacol 2006 : Our study also provides the first pharmacological evidence that Shp2 mediates EGF induced Erk1/2 MAP kinase activation
Hellmuth et al., Proc Natl Acad Sci U S A 2008 (Leukemia) : Furthermore, PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia associated Shp2 mutant, Shp2-E76K, and blocks the anchorage independent growth of a variety of human tumor cell lines
Howlett et al., Biochim Biophys Acta 2009 (Helicobacter Infections...) : It has been established that blockade of SHP2 activation of MAPK signalling results in hyperactivation of STAT3 resulting in increased cell proliferation, angiogenesis, inflammation and inhibition of both immunocyte and epithelial cell apoptosis
Chen et al., Biochem Pharmacol 2010 : Incubation of cells with SPI-112Me inhibited epidermal growth factor (EGF) stimulated Shp2 PTP activity and Shp2 mediated paxillin dephosphorylation, Erk1/2 activation , and cell migration
Chen et al., J Cell Biochem 2010 (Inflammation) : These findings highlight a novel negative regulatory role for integrin beta4 in EC inflammatory responses involving SHP-2 mediated MAPK signaling
Tartaglia et al., Molecular syndromology 2010 : SHP2 ( encoded by PTPN11 ), SOS1, BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Cascino et al., Antioxid Redox Signal 2011 (Disease Models, Animal...) : These findings provide the first evidence that adventitia derived H ( 2 ) O ( 2 ) participates in vascular dysfunction through p38 MAPK activation and SHP-2 inhibition
Fang et al., PloS one 2012 : Signaling regulatory mechanism investigation using immunoblotting, immunoprecipitation, and GST pull-down assay reveals that the down-regulation of Shp2 expression in RBL cells leads to decreased activities of Fyn, PLC?, JNK, p38MAPK , and Ras/Erk1/2 after FceR? aggregation
Li et al., J Immunol 2012 (Acute Disease...) : In vitro biochemical data correlate CSE mediated IL-8 release with Shp2 regulated epidermal growth factor receptor/Grb-2 associated binders/MAPK signaling
Zhao et al., J Biol Chem 1995 : Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen activated protein kinase activation ... Overexpression of the native PTP2C enhanced epidermal growth factor (EGF) stimulated mitogen activated protein ( MAP ) kinase activity by 30 %, whereas expression of the inactive mutant reduced the stimulated activity by 50 %
Peraldi et al., Proc Natl Acad Sci U S A 1994 : These data suggest that the EGF induced regulation of PTP2C activity is mediated by p44mapk
Bennett et al., Mol Cell Biol 1996 : Overexpression of catalytically inactive SHPTP2 ( PTP2CS ) but not catalytically inactive SHPTP1, inhibited mitogen activated protein ( MAP ) kinase activation and Elk-1 transactivation following epidermal growth factor (EGF) stimulation of 293 cells
Tsuda et al., J Biol Chem 1998 : Overexpression of a catalytically inactive SHP-2 markedly inhibited activation of mitogen activated protein ( MAP ) kinase in response to fibronectin stimulation without affecting the extent of tyrosine phosphorylation of focal adhesion kinase or its interaction with the docking protein Grb2
Deb et al., J Biol Chem 1998 : In this report we studied the role of protein-tyrosine phosphatase SHP-2 in ErbB mediated activation of mitogen activated protein kinase ( MAPK ) by overexpressing SHP-2 mutants in COS-7 cells
Myers et al., J Biol Chem 1998 : Although several reports suggest a critical role for SHP-2 in insulin stimulated mitogen activated protein kinase activation and cell proliferation, IRS-1 ( FCT ) mediated these effects normally in 32D cells