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ACE2 — ANGPT2

Text-mined interactions from Literome

Gallagher et al., Am J Physiol Cell Physiol 2006 : These data are the first to demonstrate transcriptional regulation of ACE2 by ANG II and ANG- ( 1-7 )
Gallagher et al., Am J Physiol Heart Circ Physiol 2008 : ANG II significantly reduced ACE2 activity and downregulated ACE2 mRNA in cardiac myocytes, effects blocked by the ARB losartan, indicating that ANG II regulates ACE2
Zhou et al., Tohoku J Exp Med 2009 (Carcinoma, Pancreatic Ductal...) : Therefore, ANG II may contribute to the down-regulation of ACE2
Jin et al., PloS one 2012 (Inflammation) : Furthermore, ACE2 deficiency led to greater increases in Ang II-mediated profilin-1 expression, NADPH oxidase activity, and superoxide and peroxynitrite production in the aortas of ACE2KO mice associated with enhanced phosphorylated levels of Akt, p70S6 kinase, extracellular signal regulated kinases ( ERK1/2 ) and endothelial nitric oxide synthase (eNOS)
Xiao et al., Am J Physiol Cell Physiol 2013 (MAP Kinase Signaling System) : These data suggest that ANG II increases ACE and attenuates ACE2 expression in neurons via the ANG II type 1 receptor, p38 MAPK, and ERK1/2 signaling pathways