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ANGPT1 — ANGPT2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Christensen et al., J Cell Biochem 2002
:
Hypoxia induced expression of NERF2 and Tie2 was blocked by
angiopoietin-2 , a competitive
inhibitor of
angiopoietin-1 , and by recombinant soluble extracellular domain of Tie2 but not by VEGF neutralizing antibodies
Wulff et al., Reproduction 2003
(Neovascularization, Pathologic...) :
It is hypothesized that VEGF/VEGF-R1 and Ang-1/Tie receptor 2 (Tie-2) may regulate trophoblast differentiation and invasion ; VEGF/VEGF-R2 and
Ang-1/Tie-2 may promote fetoplacental vascular development and stabilization ; and
Ang-2/Tie-2 may be
involved in maternal vascular remodelling
Ward et al., Biochem Biophys Res Commun 2004
:
Functional inhibition of secreted
angiopoietin : a novel
role for
angiopoietin 1 in coronary vessel patterning
Takazawa et al., Kidney Int 2005
(Glomerulonephritis...) :
At the early stage ( day 6 ), glomerular expression of VEGF and receptors flk-1 and flt-1 as well as
Ang-1 , and receptor Tie2 were increased, and glomerular monocyte infiltration and the expression of
angiopoietin-2 (Ang-2) , a natural antagonist of Ang-1, were
reduced
Hamada et al., Genes Dev 2005
(Neoplasms, Experimental...) :
These phenotypes depend strongly on p110gamma rather than on p85alpha and were associated with decreased expression of
Ang-1 , VCAM-1, connexin 40, and ephrinB2 but
increased expression of
Ang-2 , VEGF-A, VEGFR1, and VEGFR2
Park et al., Laryngoscope 2009
(Nasal Polyps) :
In NPs, VEGF and
Ang-1 were
detected in glandular epithelial, vascular endothelial, as well as stromal inflammatory cells, whereas
Ang-2 was detected only in stromal inflammatory cells