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BAX — MAPK14

Text-mined interactions from Literome

Deacon et al., Mol Biol Cell 2003 : Dominant-active MKK6, a direct activator of p38 MAPK, also induced cell death by stimulating translocation of Bax from the cytosol to the mitochondria in a p38 MAPK dependent manner
Choi et al., Oncogene 2004 : Elevated Bax translocation following ionizing irradiation in 12V-Ki-Ras overexpressing cells is completely inhibited by PD169316 or dominant negative p38 MAPK
Van Laethem et al., FASEB J 2004 : Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes ... UVB induced Bax translocation and mitochondrial cytochrome c release, which precede caspase activation and other endpoints of the apoptotic program such as chromatin fragmentation and loss of mitochondrial transmembrane potential, are blocked by genetic or pharmacological inhibition of the p38alpha MAPK
Harada et al., Proc Natl Acad Sci U S A 2004 : Thus, ERK/mitogen activated protein kinase dependent phosphorylation of BIM in response to survival factor regulates BIM/BAX interaction and the pro-death activity of BIM
Perfettini et al., J Exp Med 2005 (HIV Infections) : Inhibition of p38 MAPK by pharmacological inhibitors, dominant negative p38, or small interfering RNA, suppressed p53S46P ( but not p53S15P ), the expression of p53-inducible genes, the conformational activation of proapoptotic Bax and Bak, the release of cytochrome c from mitochondria, and consequent apoptosis
Choi et al., J Biol Chem 2006 (Carcinoma, Non-Small-Cell Lung...) : Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells ... Inhibition of p38 MAPK completely suppressed radiation induced Bak and Bax activations, dissipation of mitochondrial membrane potential, and cell death
Haddad et al., Protein Pept Lett 2007 (Hypoxia-Ischemia, Brain...) : The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion dependent regulation of MAPK ( ERK ) : discordant proteomic effect of MAPK ( p38 )
Sheng et al., Am J Physiol Gastrointest Liver Physiol 2007 : Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK dependent activation of Bax in intestinal epithelial cells
Kim et al., Cancer Lett 2008 (Leukemia, Promyelocytic, Acute) : Ceramide induces p38 MAPK dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells ... Pharmacological inhibition of p38 MAPK with SB203580 or expression of a dominant negative p38 MAPK attenuated DNA fragmentation, caspase-3 activation, and Bax translocation in response to ceramide
Kang et al., J Cell Physiol 2008 (Uterine Cervical Neoplasms) : Mitochondrial translocation of Bax was completely suppressed in the presence of p38 MAPK inhibitor PD169316 or si-p38 MAPK ... These results support a notion that ROS mediated activations of p38 MAPK and JNK in response to As2O3 treatment signals activation of Bax and phosphorylation of Bcl-2, resulting in mitochondrial apoptotic cell death in human cervical cancer cells
Kang et al., Oncol Rep 2008 (Uterine Cervical Neoplasms) : These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations
Mandal et al., Apoptosis 2008 (Leukemia...) : WA caused increased levels of Bax in response to MAPK signaling, which resulted in the initiation of mitochondrial death cascade, and therefore it holds promise as a new, alternative, inexpensive chemotherapeutic agent for the treatment of patients with leukemia of both lymphoid and myeloid origin
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : In contrast, inhibition of p38 MAPK led to enhanced Bax and Bak activation and mitochondrial cell death
Owens et al., Cell Death Differ 2009 : Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK ... The inhibition of p38MAPK did not prevent Bax translocation, but its activity was required for mitochondrial Bax to bring about MOMP
Yacoub et al., Mol Pharmacol 2010 (Ovarian Neoplasms) : Inhibition of p38 MAPK and JNK1/2 abolished MDA-7/IL-24 toxicity and blocked BAX and BAK activation, whereas activation of mitogen activated extracellular regulated kinase ( MEK) 1/2 or AKT suppressed enhanced killing and JNK1/2 activation
Chen et al., Toxicon 2010 : SB202190 ( p38 MAPK inhibitor ) and SP600125 ( JNK inhibitor ) suppressed CMS-9 induced dissipation of mitochondrial membrane potential, Bcl-2 down-regulation, Bax up-regulation and increased mitochondrial translocation of Bax
Shi et al., J Mol Cell Cardiol 2010 (Cardiomegaly...) : Increase in cardiomyocyte apoptosis was suppressed by ROCK1 deletion, associated with increased extracellular signal regulated kinase/mitogen activated protein kinase ( ERK/MAPK ) activation and inhibition of mitochondrial translocation of Bax
Park et al., Cancer Lett 2011 : Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal induced apoptosis of EBV transformed B cells
Wakeman et al., Am J Physiol Gastrointest Liver Physiol 2012 (Short Bowel Syndrome) : p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection
Cipak et al., Neoplasma 2012 (Leukemia...) : Inhibitors of JNK ( SP600125 ) and p38 MAPK ( SB203580 ) suppressed HEAMQ induced apoptosis and G2/M phase arrest, attenuated the activation of Bax , and blocked down-regulation of Bcl-2, XIAP and survivin in HEAMQ treated U937 cells
Yang et al., Phytother Res 2013 : The expression of p53 and its downstream genes p21 ( WAF1 ) and Bax were enhanced by blocking the activation of p42/p44 MAPK in response to treatment with vitexin
Yang et al., J Pharmacol Sci 2013 (Carcinoma, Non-Small-Cell Lung) : Altogether, our observations imply that genipin causes increased levels of Bax in response to p38MAPK signaling, which results in the initiation of mitochondrial death cascade, and therefore it holds promise as a potential chemotherapeutic agent for the treatment of H1299 cells
Bai et al., Int J Biochem Cell Biol 2013 : The disruption of mitochondrial outer membrane permeabilisation, the activation of caspase-3/7 and 9, the downregulation of Bcl-2, the upregulation of Bax , and the activation of p38 MAPK , ERK and NF-?B were all observed in HIV-1 Tat treated RPE cells