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CXCL11 — MAPK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ottonello et al., Cell Signal 2005
:
When the
activation of ERK-1/2 and p38
MAPK by CCL3 and the classical neutrophilic chemokine
CXCL8 ( IL-8 ) were compared, both the chemokines were capable of activating p38 MAPK ... When the
activation of
ERK-1/2 and p38 MAPK by CCL3 and the classical neutrophilic chemokine
CXCL8 ( IL-8 ) were compared, both the chemokines were capable of activating p38 MAPK ... On the contrary, whereas both
ERK-1 and ERK-2 were
activated by
CXCL8 , no ERK-1 band was detectable after CCL3 triggering
Méndez-Samperio et al., Cell Immunol 2005
(MAP Kinase Signaling System) :
Our data also demonstrate that M. bovis BCG induced
CXC chemokine ligand ( CXCL ) 8 release in epithelial cells was
reduced by a mitogen activated protein/ERK kinase ( MEK ) inhibitor ( PD98059 ), but not by a p38
MAPK ( SB203580 ) inhibitor
Scala et al., Clin Cancer Res 2006
(Melanoma) :
Other chemokine receptors, CCR7 and CCR10, were detected on the melanoma cell lines
; CXCL12 activated
Erk-1 and Erk-2, the whose induction was specifically inhibited by AMD3100 treatment
Lane et al., Int Immunol 2006
:
However, wild-type Cbl or its mutants had no effect on the
CXCL8 induced activation of
MAPK , indicating that Cbl specifically modulated CXCL8 induced chemotaxis
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Inhibitors of Janus kinase ( JAK ), p38
MAPK , and MAPK/ERK kinase (MEK)
suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and
CXCL11 production and NF-kappaB, STAT1, and IRF-1 activities
Kanda et al., Eur J Immunol 2007
:
Inhibitors of PI3 K, p38
MAPK , and MEK
suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and
CXCL11 production and NF-kappaB, STAT1, and IRF-1 activities
Petrai et al., Int J Biochem Cell Biol 2008
:
In human microvascular endothelial cells, which selectively express CXCR3-B, in a cell cycle dependent fashion,
CXCL10 and CXCL4
increased the enzymatic activity of p38 (
MAPK )
Gouwy et al., Mol Pharmacol 2008
:
It is noteworthy that CCL2 mediated
extracellular signal regulated kinase 1/2 phosphorylation and calcium mobilization was significantly
enhanced by
CXCL8 in monocytes, indicating cooperative downstream signaling pathways during enhanced chemotaxis
Proost et al., J Exp Med 2008
(Autoimmune Diseases...) :
In comparison with CXCL8 ( 1-77 ),
CXCL8 ( 1-77 ) Cit ( 5 ) had reduced affinity for glycosaminoglycans and
induced less CXCR2 dependent calcium signaling and
extracellular signal regulated kinase 1/2 phosphorylation
Cao et al., Microbes Infect 2010
(Pneumococcal Infections) :
Both PspA and PspC could activate p38 MAPK and NF-?B pathways in neutrophils, while inhibition of NF-?B and p38
MAPK could
suppress the release of
CXCL8 from neutrophils induced by PspA and PspC. Together, our results demonstrated that the induction of CXCL8 in human neutrophils activated by PspA and PspC was regulated by p38 MAPK and NF-?B pathways
Dogan et al., Microbes Infect 2011
:
Pneumolysin induced
CXCL8 production by nasopharyngeal epithelial cells is
dependent on calcium flux and
MAPK activation via Toll-like receptor 4
Chen et al., Molecular vision 2011
:
Inhibition of
p38MAPK , phosphoinositide 3-kinase (PI3K)-Akt and nuclear factor-kappaB ( NF-?B ), with the inhibitors SB203580, LY294002 and pyrrolydine dithiocarbamate ( PDTC ) respectively,
reduced IL-17 ( 100 ng/ml ) mediated production of
CXCL8 , CCL2, and IL-6 in a concentration dependent manner
Dumitru et al., J Leukoc Biol 2012
(Head and Neck Neoplasms...) :
Most importantly, HNC induced
p38-MAPK activation strongly
stimulates the release of CCL4,
CXCL8 , and MMP9 by neutrophils
Blume et al., Eur Respir J 2013
(Asthma...) :
Inhibition of the
extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase pathways selectively
blocked apical
CXCL8/IL-8 release via a post-transcriptional mechanism