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IL17RD — MAPK3

Text-mined interactions from Literome

Preger et al., Proc Natl Acad Sci U S A 2004 (MAP Kinase Signaling System) : hSef-b inhibits FGF induced cell proliferation and prevents the activation of mitogen activated protein kinase without affecting the upstream component MAPK kinase
Ziv et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Previously, we reported that hSef-b inhibited fibroblast proliferation and prevented the activation of mitogen activated protein kinase ( MAPK ), without affecting protein kinase B/Akt or p38 MAPK ... In epithelial cells, ectopic expression of hSef-a inhibited the activation of MAPK, whereas down-regulation of endogenous hSef-a significantly increased MAPK activation and accelerated growth factor dependent cell proliferation ... These results indicate that hSef-a is a multifunctional negative modulator of RTK signaling and clearly demonstrate that hSef-a can inhibit the activation of MAPK , although in a cell type-specific manner
Zhang et al., Gynecol Oncol 2011 (Adenocarcinoma...) : Using luciferase reporter assays and western blot analysis, we detected the effect of hSef on MAPK/ERK mediated FGF2 signaling ... We found that the hSef expression was positively regulated by FGF2 induced MAPK/ERK signaling and inversely, hSef expression efficiently inhibited the activity of FGF2 induced MAPK/ERK signaling, indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells