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MYC — PARP1

Text-mined interactions from Literome

Yu et al., Oncogene 2005 : Functionally, PARP-10 inhibits c-Myc- and E1A mediated cotransformation of rat embryo fibroblasts, a function that is independent of PARP activity but that depends on a functional NES
Chiou et al., J Exp Med 2013 : Notably, the endogenous Parp1 and PARylation activity was enhanced by overexpression of c-Myc and repressed by c-Myc knockdown ... These data show that the activation of Parp1 , partly regulated by endogenous c-Myc , effectively promotes iPSC production and helps to maintain a pluripotent state by posttranslationally modulating protein PARylation
McNerney et al., Biochem J 1987 : In lymphocytes stimulated with the mitogen phytohaemagglutinin, an inhibitor of the enzyme ADP-ribosyltransferase (ADPRT) completely blocks the proliferative response and the increase in expression of the proto-oncogene c-myc without affecting c-fos significantly