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BCL2 — HSP90AA1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dias et al., Blood 2002
(Leukemia...) :
VEGF ( 165 ) promotes survival of leukemic cells by
Hsp90 mediated induction of
Bcl-2 expression and apoptosis inhibition
Kuo et al., J Immunol 2007
:
Inhibition of
Hsp90beta suppressed the CpG-B ODN induced association of Hsp90beta with
Bcl-2 and impaired the inhibitory effect of CpG-B ODN in the release of cytochrome c and activation of caspase-3
Bansal et al., Blood 2010
(Leukemia, Myeloid) :
Furthermore,
Hsp90 inhibitors 17-AAG [ 17- ( allylamino ) -17-demethoxygeldanamycin ] and STA-9090 significantly reduced the growth of myeloid leukemia xenografts in vivo and effectively
down-regulated the expression of WT1 and its downstream target proteins, c-Myc and
Bcl-2
Bansal et al., J Biol Chem 2012
(Leukemia, Myeloid, Acute) :
Consistent with this, pharmacological inhibition of
Hsp90 resulted in reduced WT1 and
Bcl-xL expression leading to increased sensitivity of leukemia cells to TRAIL mediated apoptosis