◀ Back to BCL2
BCL2 — PRKAR2A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chin et al., Exp Mol Med 2005
(Neoplasms) :
We also revealed that the combined treatment of radiation and the inhibitor of
protein kinase A (PKA) to these radioresistant cells
resulted in synergistic inhibition of DNA-PK, Rad51 and
Bcl-2 expressions of the cells, and consequently restored radiosensitivity of the cells
O'Driscoll et al., J Neurochem 2007
:
Activation of the transcription factor cAMP-response element binding protein ( CREB ) and subsequent up-regulation of
Bcl-2 in response to bFGF was also
dependent on
PKA as inhibition with H-89 attenuated increased pCREB levels and Bcl-2 expression ... These results indicate that the protective efficacy of bFGF in mouse photoreceptors involves
PKA dependent inactivation of GSK3beta and subsequent up-regulation of
Bcl-2 via CREB activation
Itano et al., J Neurochem 1996
(Neuroblastoma) :
From these results, we suggest that the expression of
Bcl-2 proteins is
regulated by PKC and
PKA in positive and negative manners, respectively, in SH-SY5Y cells
Srivastava et al., Mol Cell Biol 1998
(Breast Neoplasms...) :
In addition, paclitaxel- and vincristine induced activation of cyclic AMP ( cAMP ) -dependent protein kinase ( protein kinase A
[PKA ] )
induced Bcl2 hyperphosphorylation and apoptosis, which were blocked by the PKA inhibitor Rp diastereomers of cAMP ( Rp-cAMP )
Venkataraman et al., Mol Immunol 1998
:
PKA-activation caused a downregulation of anti-IgM induced expression of
Bcl-xL protein, that was restored by IL-4