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FGF2 — PCNA
Text-mined interactions from Literome
Weng et al., Zhonghua Yan Ke Za Zhi 2002
:
To observe the effect of the expression of
proliferating cell nuclear antigen ( PCNA )
induced by
basic fibroblast growth factor (bFGF) on the proliferation of bovine lens epithelial cells ( BLECs )
Frederick et al., Mol Cell Neurosci 2004
:
IGF-I and
FGF-2 coordinately
enhance cyclin D1 and
cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells ... IGF-I enhanced
FGF-2 induction of cyclin D1, activation of G ( 1 )
cyclin-cyclin dependent kinase (cdk) complexes, and hyperphosphorylation of retinoblastoma protein ( pRb )
Neary et al., Purinergic Signal 2005
:
Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase ( ERK ), a key member of a signaling cascade that regulates proliferation, we also investigated the role of ERK in regulating
cyclin expression
induced by
FGF2 and ATP ... P2 receptor agonist studies revealed that UTP enhanced
FGF2 induced
cyclin expression and mitogenesis whereas 2-methylthioADP was ineffective
Katayama et al., Int J Oncol 2010
(Prostatic Neoplasms) :
Overall, bicalutamide
inhibits the
cyclin A expression possibly by inhibiting FGF-8 mRNA expression and FGF-8 protein secretion but not by inhibiting
FGF receptor ( FGFR ) signalling in androgen dependent cell lines, and by other mechanisms in androgen independent cell lines
Kolupaeva et al., Cell cycle (Georgetown, Tex.) 2012
:
In cells overexpressing cyclin D1/CDK4,
FGF induced downregulation of
cyclin E/CDK2 activity was absent
Bravo et al., EMBO J 1984
:
In addition, partially purified PDGF and
FGF also
induce cyclin and DNA synthesis in a coordinate way
Rao et al., J Biol Chem 1995
:
Positive and negative
regulation of D-type
cyclin expression in skeletal myoblasts by
basic fibroblast growth factor and transforming growth factor beta ... We investigated the
effects of
bFGF and TGF beta on D-type
cyclin expression in skeletal myoblasts
Wang et al., Cancer Res 1997
:
bFGF induced an increase in cyclin D1, cyclin E, and
cyclin dependent kinase 4 (cdk4) protein levels in a bFGF dose dependent manner ... These experiments demonstrate that stimulation of MCF-7 cells with
bFGF , although resulting in up-regulation of G1 proteins responsible for mitogenic events, also
induces a concomitant decrease in
cyclin A levels and an increase in p21 ( WAF1/CIP1 ) mRNA and protein and results in inactivation of cdk2, dephosphorylation of Rb, and a segregation of PCNA to the G1 cyclin complexes
Murakami-Mori et al., J Immunol 1998
(Acquired Immunodeficiency Syndrome...) :
Thus,
FGF actions are
essential for
cyclin E-CDK2 activity and S phase entry ... Endogenous
basic fibroblast growth factor is
essential for
cyclin E-CDK2 activity in multiple external cytokine induced proliferation of AIDS associated Kaposi 's sarcoma cells : dual control of AIDS associated Kaposi 's sarcoma cell growth and cyclin E-CDK2 activity by endogenous and external signals