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IL1A — PRKAR2B

Text-mined interactions from Literome

Murray et al., J Recept Signal Transduct Res 2009 : These findings indicate that cAMP/PKA serves as a point of convergence for regulation of IL-1alpha responses by multiple G ( s ) -coupled receptors and regulates IL-1alpha responses by a distinct mechanism that does not solely involve direct inhibition of p38, JNK, MEK or IKK
Gwosdow et al., Am J Physiol 1994 : The present studies were conducted to determine if cAMP is involved in IL-1 alpha activation of PKA and if PKA is responsible for IL-1 alpha induced ACTH release from AtT-20 cells ... Inhibition of adenylate cyclase with 2'5'-dideoxyadenosine ( 2'5'-DDA ) did not affect IL-1 alpha induced increases in PKA activity and ACTH secretion ... IBMX did not alter IL-1 alpha induced PKA activity or ACTH secretion, yet IBMX potentiated CRF induced cAMP accumulation ... Inhibition of PKA with the PKA inhibitor, H-8, blocked activation of PKA and ACTH secretion by both IL-1 alpha and CRF in AtT-20 cells ... These observations demonstrate that 1 ) the mechanism of IL-1 alpha activation of PKA is independent of adenylate cyclase or cAMP and 2 ) PKA is used by IL-1 alpha to induce ACTH secretion from AtT-20 cells
Manié et al., J Biol Chem 1993 : The use of different protein kinase inhibitors supported a role of the PKA , but not the PKC, in the colchicine induced IL-1 production
Aksamit et al., J Immunol 1993 : In addition, since IL-1 and PGE2 can activate protein kinase C ( PKC ) and protein kinase A (PKA) , we exposed human lung fibroblasts to 1- ( 5-Isoquinoline sulfonyl ) -2-methylpiperafine ( H7 ) or staurosporine, which are relatively specific inhibitors of PKC, and N- [ 2- ( methylamino ) ethyl ] -5-isoquinolinesulfomamide ( H8 ), an inhibitor of PKA, to determine whether the IL-1 and PGE2 stimulated increases in binding sites were mediated by activation of PKC or PKA
Gwosdow et al., Endocrinology 1993 (Pituitary Neoplasms) : Because IL-1 did not affect cAMP accumulation, the effect of IL-1 on protein kinase A (PKA) was investigated
Joseph et al., Am J Physiol 1995 : Because IL-1 alpha did not affect cAMP accumulation, the effect of IL-1 alpha on PKA activity was investigated ... IL-1 alpha increased ( P < 0.05 ) PKA activity at 15 and 30 min and returned to control levels by 1 h. Forskolin also increased ( P < 0.05 ) PKA activity ... These observations demonstrate that 1 ) IL-1 alpha stimulated dopamine release from PC-12 cells by activating PKA, 2 ) the mechanism of IL-1 alpha activation of PKA does not involve detectable increases in intracellular cAMP accumulation, and 3 ) IL-1 alpha activates type II PKA, which is used by IL-1 alpha to stimulate dopamine secretion from PC-12 cells