Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Iliopoulos et al., Cancer Res 2009 (Adrenal Cortex Diseases...) : Using a PPNAD cell line, we showed that miR-449 was up-regulated and identified its direct target, WNT1-inducible signaling pathway protein 2 ( WISP2 ) ; in addition, pharmacologic inhibition of PKA resulted in the up-regulation of miR-449 leading to the suppression of WISP2
Lv et al., Leukemia 2012 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : High levels of miR-142-3p resulted in low levels of cAMP and weak activity of PKA , thus relieving the inhibitory effect of PKA on T-leukemic cell proliferation
Ghorpade et al., Mol Cell Biol 2012 : Genetic and signaling perturbations presented the evidence that miR-155 regulates PKA signaling by directly targeting a negative regulator of PKA, protein kinase inhibitor alpha ( PKI-a )