Gene interactions and pathways from curated databases and text-mining

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PRKAR2B — RPS6KA1

Text-mined interactions from Literome

Ahi et al., Behav Brain Res 2004 : Inhibition of PKA impaired context- and tone dependent fear conditioning and significantly reduced the phosphorylation of Elk-1, p90Rsk-1 , Erk-1/2, and CREB
Chaturvedi et al., J Biol Chem 2009 : Previously, we showed that interactions between p90 ( RSK1 ) ( RSK1 ) and the subunits of type I protein kinase A (PKA) regulate the activity of PKA and cellular distribution of active RSK1 ( Chaturvedi, D., Poppleton, H. M., Stringfield, T., Barbier, A., and Patel, T. B. ( 2006 ) Mol. Cell Biol. 26, 4586-4600 )
Gao et al., J Biol Chem 2009 : RSK1 attenuated the ability of cAMP to activate PKA in vitro and this modulation was abrogated by peptide E, but not by peptide A ... These findings demonstrate that interactions between endogenous RSK1 and PKAc in intact cells regulate the ability of cAMP to activate PKA and identify a novel mechanism by which PKA activity is regulated by the Erk1/2 pathway